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ppe12131-sup-0001-figures1.doc82K

Figure S1.  Quality assessment of included case–control and cohort studies using the Newcastle–Ottawa scale.

ppe12131-sup-0002-figures2.doc29K

Figure S2.  Forest plot – odds ratios for association between alcohol consumption during pregnancy and OFCs.

ppe12131-sup-0005-tables1.doc73K

Table S1.  Characteristics of case–control studies reporting maternal alcohol consumption in pregnancy and occurrence of orofacial clefts.

ppe12131-sup-0006-tables2.doc46K

Table S2.  Characteristics of cohort studies reporting maternal alcohol consumption in pregnancy and occurrence of orofacial clefts.

ppe12131-sup-0007-tables3.doc71K

Table S3.  Association between OFC types and alcohol consumption during pregnancy at heavy and moderate levels.

ppe12131-sup-0008- tables4.doc51K

Table S4.  Dose–response relationship between maternal alcohol consumption in first trimester and infants with CL ± P and CPO, within studies.

ppe12131-sup-0003- appendixs1.doc63K

Appendix S1.  Sensitivity analyses.

ppe12131-sup-0004-appendixs2.doc32K

Appendix S2.  Funnel plots and tests for funnel plot asymmetry.

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