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Pharmacology Research & Perspectives

Cover image for Vol. 2 Issue 2

April 2014

Volume 2, Issue 2

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Articles
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      Issue Information

      Version of Record online: 12 MAR 2014 | DOI: 10.1002/prp2.40

  2. Original Articles

    1. Top of page
    2. Issue Information
    3. Original Articles
    1. You have full text access to this OnlineOpen article
      The potent and selective α4β2*/α6*-nicotinic acetylcholine receptor partial agonist 2-[5-[5-((S)Azetidin-2-ylmethoxy)-3-pyridinyl]-3-isoxazolyl]ethanol demonstrates antidepressive-like behavior in animal models and a favorable ADME-tox profile

      Li-Fang Yu, J. Brek Eaton, Han-Kun Zhang, Emily Sabath, Taleen Hanania, Guan-Nan Li, Richard B. van Breemen, Paul Whiteaker, Qiang Liu, Jie Wu, Yong-Chang Chang, Ronald J. Lukas, Dani Brunner and Alan P. Kozikowski

      Version of Record online: 12 MAR 2014 | DOI: 10.1002/prp2.26

      e00026

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      A clinical therapeutic protein drug–drug interaction study: coadministration of denosumab and midazolam in postmenopausal women with osteoporosis

      Graham Jang, Allegra Kaufman, Edward Lee, Lisa Hamilton, Shauna Hutton, Ogo Egbuna and Desmond Padhi

      Version of Record online: 13 MAR 2014 | DOI: 10.1002/prp2.33

      e00033

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      Species differences in sinusoidal and canalicular efflux transport of mycophenolic acid 7-O-glucuronide in sandwich-cultured hepatocytes

      Kazuhiro Tetsuka, Nicolas Gerst, Kouichi Tamura and Jeffrey N. Masters

      Version of Record online: 24 MAR 2014 | DOI: 10.1002/prp2.35

      e00035

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      Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo.

      Martha Kampp Nøhr, Zia I. Thale, Birger Brodin, Steen H. Hansen, René Holm and Carsten Uhd Nielsen

      Version of Record online: 24 MAR 2014 | DOI: 10.1002/prp2.36

      e00036

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      From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease

      Andrea Tarozzi, Manuela Bartolini, Lorna Piazzi, Luca Valgimigli, Riccardo Amorati, Cecilia Bolondi, Alice Djemil, Francesca Mancini, Vincenza Andrisano and Angela Rampa

      Version of Record online: 24 MAR 2014 | DOI: 10.1002/prp2.23

      e00023

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      Inhibition of the dorsomedial hypothalamus, but not the medullary raphe pallidus, decreases hyperthermia and mortality from MDMA given in a warm environment

      Dmitry V. Zaretsky, Maria V. Zaretskaia, Pamela J. Durant and Daniel E. Rusyniak

      Version of Record online: 1 APR 2014 | DOI: 10.1002/prp2.31

      e00031

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      Orthovanadate-induced vasocontraction is mediated by the activation of Rho-kinase through Src-dependent transactivation of epidermal growth factor receptor

      Katsutoshi Yayama, Tomoya Sasahara, Hisaaki Ohba, Ayaka Funasaka and Hiroshi Okamoto

      Version of Record online: 1 APR 2014 | DOI: 10.1002/prp2.39

      e00039

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