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Pharmacology Research & Perspectives

Cover image for Vol. 2 Issue 4

August 2014

Volume 2, Issue 4

  1. Issue Information

    1. Top of page
    2. Issue Information
    3. Original Articles
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      Issue Information

      Article first published online: 9 JUN 2014 | DOI: 10.1111/prp2.55

  2. Original Articles

    1. Top of page
    2. Issue Information
    3. Original Articles
    1. You have full text access to this OnlineOpen article
    2. You have full text access to this OnlineOpen article
      The in vivo efficacy and side effect pharmacology of GS-5759, a novel bifunctional phosphodiesterase 4 inhibitor and long-acting β2-adrenoceptor agonist in preclinical animal species

      Michael Salmon, Stacey L. Tannheimer, Terry T. Gentzler, Zhi-Hua Cui, Eric A. Sorensen, Kimberly C. Hartsough, Musong Kim, Lafe J. Purvis, Edward G. Barrett, Jacob D. McDonald, Karin Rudolph, Melanie Doyle-Eisele, Philip J. Kuehl, Christopher M. Royer, William R. Baker, Gary B. Phillips and Clifford D. Wright

      Article first published online: 9 JUN 2014 | DOI: 10.1002/prp2.46

      e00046

    3. You have full text access to this OnlineOpen article
    4. You have full text access to this OnlineOpen article
      Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model

      Olga Andersson, Liesbeth Badisco, Ane Håkansson Hansen, Steen Honoré Hansen, Karin Hellman, Peter Aadal Nielsen, Line Rørbæk Olsen, Rik Verdonck, N. Joan Abbott, Jozef Vanden Broeck and Gunnar Andersson

      Article first published online: 9 JUN 2014 | DOI: 10.1002/prp2.50

      e00050

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      Gene expression analysis of membrane transporters and drug-metabolizing enzymes in the lung of healthy and COPD subjects

      Tove Berg, Tove Hegelund Myrbäck, Marita Olsson, Janeric Seidegård, Viktoria Werkström, Xiao-Hong Zhou, Johan Grunewald, Lena Gustavsson and Magnus Nord

      Article first published online: 12 JUN 2014 | DOI: 10.1002/prp2.54

      e00054

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      Inhibition of Let-7 microRNA attenuates myocardial remodeling and improves cardiac function postinfarction in mice

      Anna-Maria Tolonen, Johanna Magga, Zoltán Szabó, Pirkko Viitala, Erhe Gao, Anne-Mari Moilanen, Pauli Ohukainen, Laura Vainio, Walter J. Koch, Risto Kerkelä, Heikki Ruskoaho and Raisa Serpi

      Article first published online: 12 JUN 2014 | DOI: 10.1002/prp2.56

      e00056

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      PDE10A inhibitors stimulate or suppress motor behavior dependent on the relative activation state of the direct and indirect striatal output pathways

      Anton A. H. P. Megens, Herman M. R. Hendrickx, Michel M. A. Mahieu, Annemie L. Y. Wellens, Peter de Boer and Greet Vanhoof

      Article first published online: 12 JUN 2014 | DOI: 10.1002/prp2.57

      e00057

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      Investigating the potential role of TRPA1 in locomotion and cardiovascular control during hypertension

      Jennifer V. Bodkin, Pratish Thakore, Aisah A. Aubdool, Lihuan Liang, Elizabeth S. Fernandes, Manasi Nandi, Domenico Spina, James E. Clark, Philip I. Aaronson, Michael J. Shattock and Susan D. Brain

      Article first published online: 23 JUN 2014 | DOI: 10.1002/prp2.52

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