We thank Shuang Liu for data collection and removal of artifacts. We owe a special debt of gratitude to Peri Ktonas and Ben Jansen for generous guidance in the analysis.
Sound-induced perturbations of the brain network in non-REM sleep, and network oscillations in wake
Article first published online: 14 JAN 2013
Copyright © 2013 Society for Psychophysiological Research
Volume 50, Issue 3, pages 274–286, March 2013
How to Cite
Wu, W. and Sheth, B. R. (2013), Sound-induced perturbations of the brain network in non-REM sleep, and network oscillations in wake. Psychophysiology, 50: 274–286. doi: 10.1111/psyp.12011
- Issue published online: 5 FEB 2013
- Article first published online: 14 JAN 2013
- Manuscript Accepted: 22 OCT 2012
- Manuscript Received: 16 JAN 2012
- Unconscious Processes;
- Normal volunteers;
- Auditory processing/Sensory processing
During sleep, the brain network processes sensory stimuli without awareness. Stimulation must affect differently brain networks in sleep versus wake, but these differences have yet to be quantified. We recorded cortical activity in stage 2 (SII) sleep and wake using EEG while a tone was intermittently played. Zero-lag correlation measured input to pairs of sensors in the network; cross-correlation and phase-lag index measured pairwise corticocortical connectivity. Our analysis revealed that under baseline conditions, the cortical network, in particular the central regions of the frontoparietal cortex, interact at a characteristic latency of 50 ms, but only during wake, not sleep. Nonsalient auditory stimulation causes far greater perturbation of connectivity from baseline in sleep than wake, both in the response to common input and corticocortical connectivity. The findings have key implications for sensory processing.