This work was supported by the Deutsche Forschungsgemeinschaft (grant number DFG WA 2593/2-1). We would like to thank Dipl. Psych. I. Mayer who performed parts of the data analysis as part of her Diploma thesis. Parts of this work have been presented in preliminary form at the 51st Annual Meeting of the Society for Psychophysiological Research in Boston, Massachusetts, in 2011.
5-HTTLPR and anxiety modulate brain-heart covariation
Article first published online: 27 FEB 2013
Copyright © 2013 Society for Psychophysiological Research
Volume 50, Issue 5, pages 441–453, May 2013
How to Cite
Mueller, E. M., Stemmler, G., Hennig, J. and Wacker, J. (2013), 5-HTTLPR and anxiety modulate brain-heart covariation. Psychophysiology, 50: 441–453. doi: 10.1111/psyp.12016
- Issue published online: 1 APR 2013
- Article first published online: 27 FEB 2013
- Manuscript Accepted: 28 NOV 2012
- Manuscript Received: 1 OCT 2012
- Deutsche Forschungsgemeinschaft. Grant Number: DFG WA 2593/2-1
- Heart rate;
To date, little is known about genes affecting the interplay of brain and heart activity. Because serotonin (5-HT) is involved in corticovagal neurotransmission, we tested whether the 5-HT transporter polymorphism 5-HTTLPR affects brain-heart covariation. Further, associations with neuroticism/anxiety (NANX) were tested, as anxiety is related to 5-HT and neurogenic changes of heart period (HP). N = 168 participants performed a time-estimation task while EEG and HP were recorded. Brain-heart covariation was measured using time-lagged within-subject correlations of centromedial feedback-evoked single-trial EEG at 300 ms and subsequent changes of HP. EEG-HP correlations were higher in 5-HTTLPR long allele carriers. Moreover, after negative feedback, EEG-HP correlations and feedback-related negativity amplitudes independently correlated with NANX. The results indicate that individual differences in brain-heart covariation relate to 5-HT and NANX.