Neuroticism relates to daytime wakefulness and sleep devaluation via high neurophysiological efficiency in the bilateral prefrontal cortex: A preliminary study

Authors

  • Takuya Yoshiike,

    1. Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    2. Section of Psychiatry and Behavioral Science, Tokyo Medical and Dental University Graduate School, Tokyo, Japan
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  • Kenichi Kuriyama,

    Corresponding author
    1. Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
    • Address correspondence to: Kenichi Kuriyama, MD, PhD, Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, 4-1-1 Ogawa-Higashi, Kodaira 187-8502, Japan. E-mail: kenichik@ncnp.go.jp

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  • Motoyasu Honma,

    1. Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
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  • Hiroki Ikeda,

    1. Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
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  • Yoshiharu Kim

    1. Department of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan
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  • We thank S. Koyama, M. Shimazaki, and M. Kimura for experimental support. We also thank Professor T. Nishikawa for his thoughtful suggestions and comments on this research. This work was funded by grants from the Core Research for Evolutional Science and Technology (CREST) program from the Japan Science and Technology (JST) Corporation, the Grant-in-Aid for Scientific Research (#25670122) from the Ministry of Education, Sports, Science, and Culture of Japan, the Japan Foundation for Neuroscience and Mental Health, the Takeda Science Foundation, and the SENSHIN Medical Research Foundation.

Abstract

Higher wake promotion against sleep drive boosts cognitive processing, but it also seems to increase the risk of insomnia by reinforcing an obsession with sleep in neurotic patients. To explore whether a personality trait of neuroticism simultaneously facilitates wake-promoting ability and sleep devaluation via a common regional prefrontal function under a sleep-restricted condition, working memory tasks were administered to 49 healthy humans after a 2-h sleep restriction. Higher wake-promoting ability demonstrated in a high-load task was correlated with lower bilateral prefrontal activation, as measured by near-infrared spectroscopy. Structural equation modeling revealed that neuroticism predicts sleep devaluation and wake-promoting ability via left and right regional prefrontal efficiency, respectively. Our results indicate that neuroticism-related neural efficiency increases resilience to sleepiness, but decreases sleep satisfaction.

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