This research was supported by National Institute of Mental Health Grants R01 MH084932-02, R01 MH097320, the Ministerio de Ciencia e Innovación Grant I + D + i PSI2009-07066 awarded to A.K. and an American Psychological Association Dissertation Award by Science Directorate to I.S.
Differential classical conditioning selectively heightens response gain of neural population activity in human visual cortex
Article first published online: 1 JUL 2014
Copyright © 2014 Society for Psychophysiological Research
Volume 51, Issue 11, pages 1185–1194, November 2014
How to Cite
Song, I. and Keil, A. (2014), Differential classical conditioning selectively heightens response gain of neural population activity in human visual cortex. Psychophysiology, 51: 1185–1194. doi: 10.1111/psyp.12260
- Issue published online: 12 OCT 2014
- Article first published online: 1 JUL 2014
- Manuscript Accepted: 13 MAY 2014
- Manuscript Received: 14 JAN 2014
- National Institute of Mental Health Grants. Grant Numbers: R01 MH084932-02, R01 MH097320
- Ministerio de Ciencia e Innovación Grant. Grant Number: I + D + i PSI2009-07066
- Differential fear conditioning;
- Response gain
Neutral cues, after being reliably paired with noxious events, prompt defensive engagement and amplified sensory responses. To examine the neurophysiology underlying these adaptive changes, we quantified the contrast-response function of visual cortical population activity during differential aversive conditioning. Steady-state visual evoked potentials (ssVEPs) were recorded while participants discriminated the orientation of rapidly flickering grating stimuli. During each trial, luminance contrast of the gratings was slowly increased and then decreased. Right-tilted gratings (CS+) were paired with loud white noise but left-tilted gratings (CS−) were not. The contrast-following waveform envelope of ssVEPs showed selective amplification of the CS+ only during the high-contrast stage of the viewing epoch. Findings support the notion that motivational relevance, learned in a time frame of minutes, affects vision through a response gain mechanism.