This work was supported by a post-doctoral grant (BPD/68967/2010) and FCT Investigator Grant (IF/00334/2012) from Fundação para a Ciência e a Tecnologia (FCT; Portugal) awarded to APP, by a research grant (PTDC/PSI-PCL/116626/2010) funded by FCT and by European Regional Development Fund awarded to APP, and by two grants from the National Institute of Mental Health (NIMH; RO1 MH 040799 grant awarded to RWM; RO3 MH 078036 grant awarded to MAN). We gratefully acknowledge all the participants of this study for their contribution to science. Many thanks also to Elizabeth Thompson for her help with data acquisition, and to two anonymous reviewers for their insightful and helpful comments on earlier versions of this manuscript.
Abnormal interactions between context, memory structure, and mood in schizophrenia: An ERP investigation
Version of Record online: 22 JUL 2014
Copyright © 2014 Society for Psychophysiological Research
Volume 52, Issue 1, pages 20–31, January 2015
How to Cite
Pinheiro, A. P., Del Re, E., Nestor, P. G., Mezin, J., Rezaii, N., McCarley, R. W., Gonçalves, Ó. F. and Niznikiewicz, M. (2015), Abnormal interactions between context, memory structure, and mood in schizophrenia: An ERP investigation. Psychophysiology, 52: 20–31. doi: 10.1111/psyp.12289
- Issue online: 24 DEC 2014
- Version of Record online: 22 JUL 2014
- Manuscript Accepted: 8 JUN 2014
- Manuscript Received: 4 MAR 2014
- Fundação para a Ciência e a Tecnologia (FCT; Portugal). Grant Numbers: BPD/68967/2010, IF/00334/2012, PTDC/PSI-PCL/116626/2010
- European Regional Development Fund
- National Institute of Mental Health. Grant Numbers: RO1 MH 040799, RO3 MH 078036
- Semantic memory;
This study used event-related potentials to examine interactions between mood, sentence context, and semantic memory structure in schizophrenia. Seventeen male chronic schizophrenia and 15 healthy control subjects read sentence pairs after positive, negative, or neutral mood induction. Sentences ended with expected words (EW), within-category violations (WCV), or between-category violations (BCV). Across all moods, patients showed sensitivity to context indexed by reduced N400 to EW relative to both WCV and BCV. However, they did not show sensitivity to the semantic memory structure. N400 abnormalities were particularly enhanced under a negative mood in schizophrenia. These findings suggest abnormal interactions between mood, context processing, and connections within semantic memory in schizophrenia, and a specific role of negative mood in modulating semantic processes in this disease.