Respirology

Cover image for Vol. 16 Issue 5

July 2011

Volume 16, Issue 5

Pages 723–870

  1. EDITORIAL

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. You have free access to this content
      Primum non nocere: Safety in clinical trials for IPF (pages 723–724)

      Joyce S. Lee and Harold R. Collard

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01971.x

  2. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. You have free access to this content
      Bronchial brushings for investigating airway inflammation and remodelling (pages 725–737)

      KEVIN LOOI, ERIKA N. SUTANTO, BALARKA BANERJEE, LUKE GARRATT, KAK-MING LING, CLARA J. FOO, STEPHEN M. STICK and ANTHONY KICIC

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.02001.x

  3. INVITED REVIEW SERIES: PLEURAL DISEASE

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. You have free access to this content
      Pleural controversy: Closed needle pleural biopsy or thoracoscopy—Which first? (pages 738–746)

      COENRAAD F.N. KOEGELENBERG and ANDREAS H. DIACON

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01973.x

    2. You have free access to this content
  4. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. You have free access to this content
      Respiratory disorders in the Middle East: A review (pages 755–766)

      ABDELKARIM WANESS, YASER ABU EL-SAMEED, BASSAM MAHBOUB, MOHAMMED NOSHI, HAMDAN AL-JAHDALI, MAYANK VATS and ATUL C. MEHTA

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01988.x

  5. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. You have free access to this content
      Asbestos use and asbestos-related diseases in Asia: Past, present and future (pages 767–775)

      GIANG VINH LE, KEN TAKAHASHI, EUN-KEE PARK, VANYA DELGERMAA, CHULHO OAK, AHMAD MUNIR QURESHI and SYED MOHAMED ALJUNID

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01975.x

  6. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. An investigator-driven study of everolimus in surgical lung biopsy confirmed idiopathic pulmonary fibrosis (pages 776–783)

      MONIQUE A. MALOUF, PETER HOPKINS, GREGORY SNELL and ALLAN R. GLANVILLE

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01955.x

      Eighty-nine patients were randomized to receive everolimus or placebo as treatment for IPF. The everolimus group fared less well than those given placebo.

    2. Comparison of high-dose salmeterol/fluticasone and moderate-dose salmeterol/fluticasone plus low-dose mometasone in patients with severe persistent asthma (pages 784–789)

      KAZUYOSHI KURASHIMA, NAHO KAGIYAMA, NOBORU TAKAYANAGI and YUTAKA SUGITA

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01967.x

      Salmeterol/fluticasone propionate 50/250 µg plus mometasone 100 µg bd was superior to SFC 50/500 µg bd in patients whose asthma was not controlled with SFC 50/250 µg bd. A combination of inhaled corticosteroids with large and small particle sizes may be more efficacious than higher doses of a single corticosteroid.

    3. Lack of association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis: A meta-analysis (pages 790–795)

      XIWEN WANG, HUAPING XIAO, HAIBING LAN, CHEN MAO and QING CHEN

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01976.x

      The results from this first meta-analysis indicated that there is no association between the P2X7 receptor A1513C polymorphism and susceptibility to pulmonary tuberculosis.

    4. Hypoxia-inducible factor-1α polymorphisms are associated with genetic aberrations in lung cancer (pages 796–802)

      ANDIKA C. PUTRA, KEIJI TANIMOTO, MARINA ARIFIN and KEIKO HIYAMA

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01972.x

      The HIF-1αC1772T and G1790A variants showed enhanced transcriptional activity, especially with mutant p53, under hypoxic conditions in vitro, and are associated with TP53 and/or 1p34 LOH in lung adenocarcinomas in vivo, indicating that these polymorphisms may have an impact on carcinogenesis of lung adenocarcinoma, possibly through increases in genomic instability.

    5. Effect of spirometry and medical review on asthma control in patients in general practice: A randomized controlled trial (pages 803–810)

      SIAO MING OEI, FRANCIS C.K. THIEN, ROSA L. SCHATTNER, NABIL D. SULAIMAN, KATE BIRCH, PAM SIMPSON, ELEONORA A. DEL COLLE, ROSALIE A. ARONI, RORY WOLFE and MICHAEL J. ABRAMSON

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01969.x

      Despite the guidelines recommending use of spirometry for asthma management, it remains underused in general practice. Spirometry with regular medical review was associated with significantly improved asthma control in patients in general practice.

    6. Exhaled nitric oxide and exhaled breath condensate pH as predictors of sputum cell counts in optimally treated asthmatic smokers (pages 811–818)

      GEORGIOS HILLAS, KONSTANTINOS KOSTIKAS, KONSTANTINOS MANTZOURANIS, VASSILIKI BESSA, KONSTANTINA KONTOGIANNI, GEORGIA PAPADAKI, SPYROS PAPIRIS, MANOS ALCHANATIS, STELIOS LOUKIDES and PETROS BAKAKOS

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01984.x

      Smoking may modify the pattern of airway inflammation. Asthmatics who smoked had lower exhaled NO (FeNO) and exhaled breath condensate (EBC) pH compared with asthmatic non-smokers. Smokers with well-controlled asthma mainly showed a paucigranulocytic induced sputum phenotype, which may be predicted by combined specific cut-off values for FeNO and EBC pH.

    7. Procalcitonin guidance for reduction of antibiotic use in low-risk outpatients with community-acquired pneumonia (pages 819–824)

      WEI LONG, XINGQI DENG, YU ZHANG, GANG LU, JUAN XIE and JIANGUO TANG

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01978.x

      Antibiotic use in outpatients with community-acquired pneumonia is determined empirically, which may lead to overuse and selection pressure for resistance. Procalcitonin guidance allows a reduction in antibiotic use and shortening of the duration of antibiotic therapy in low-risk outpatients with community-acquired pneumonia, without apparent harm.

    8. Efficacy of tiotropium in COPD patients from Asia: A subgroup analysis from the UPLIFT trial (pages 825–835)

      YOSHINOSUKE FUKUCHI, LENORA FERNANDEZ, HAN-PIN KUO, AZIAH MAHAYIDDIN, BARTOLOME CELLI, MARC DECRAMER, STEVEN KESTEN, DACHENG LIU and DONALD TASHKIN

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01982.x

      Subgroup analysis of Asian subjects with COPD enrolled in the international multi-centre UPLIFT trial demonstrates that this population benefits from treatment with inhaled tiotropium. For subjects receiving tiotropium, improvements were observed in lung function, exacerbation frequency, health-related quality of life and mortality.

      Corrected by:

      CORRIGENDUM

      Vol. 16, Issue 8, 1281, Article first published online: 27 OCT 2011

    9. Clinical significance of normal chest radiographs among HIV-seropositive patients with suspected tuberculosis in Uganda (pages 836–841)

      SAMUEL D. YOO, ADITHYA CATTAMANCHI, SASKIA DEN BOON, WILLIAM WORODRIA, HARRIET KISEMBO, LAURENCE HUANG and J. LUCIAN DAVIS

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01981.x

      The frequency and outcomes of normal CXRs among HIV-seropositive patients with suspected pulmonary tuberculosis have been infrequently described. Normal CXRs were common in this population, and mortality among these patients was high. Normal CXRs should not preclude further diagnostic evaluation in this population.

    10. Neurocognitive impairment in Chinese patients with obstructive sleep apnoea hypopnoea syndrome (pages 842–848)

      RUI CHEN, KANG-PING XIONG, JUAN-YING HUANG, YI-XIN LIAN, FA JIN, ZHEN-HUA LI, MIN-YAN ZHAO and CHUN-FENG LIU

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01979.x

      This study compared MoCA and MMSE for assessing cognitive function in OSAHS patients. OSAHS was frequently associated with neurocognitive impairment that was detected with MoCA but not MMSE. MoCA scores correlated with disease severity and polysomnographic parameters. MoCA is a rapid sensitive tool for detecting cognitive impairment in OSAHS.

    11. Reversibility of impaired nasal mucociliary clearance in smokers following a smoking cessation programme (pages 849–855)

      ERCY MARA CIPULO RAMOS, ALESSANDRA CHOQUETA DE TOLEDO, RAFAELLA FAGUNDES XAVIER, LUCIANA CRISTINA FOSCO, RODOLFO PAULA VIEIRA, DIONEI RAMOS and JOSÉ ROBERTO JARDIM

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01985.x

      Mucociliary clearance was measured in smokers enrolled in a Smoke Cessation Intervention Programme. Impairment of nasal mucociliary transport in smokers was reversed from the 15th day after cessation of smoking, and these beneficial effects persisted for 6 months.

    12. Clinical features of healthcare-associated pneumonia (HCAP) in a Japanese community hospital: Comparisons among nursing home-acquired pneumonia (NHAP), HCAP other than NHAP, and community-acquired pneumonia (pages 856–861)

      KENJI UMEKI, ISSEI TOKIMATSU, CHIE YASUDA, ATSUKO IWATA, DAISUKE YOSHIOKA, HIROSHI ISHII, RYO SHIRAI, KENJI KISHI, KAZUFUMI HIRAMATSU, BUNROKU MATSUMOTO and JUN-ICHI KADOTA

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01983.x

      There were differences in bacteriological findings and mortality rates among subgroups of Japanese patients with healthcare-associated pneumonia (HCAP). The HCAP guidelines of the American Thoracic Society/Infectious Diseases Society of America may not necessarily be applicable for accurate diagnosis and optimum treatment of all Japanese patients with HCAP.

    13. Comparison of alveolar nitric oxide concentrations using two different methods for assessing small airways obstruction in asthma (pages 862–868)

      DAIKI KOBAYASHI, YOSHIHIRO TOCHINO, HIROSHI KANAZAWA, YUKIKAZU ICHIMARU, SHIGENORI KYOH, KAZUHISA ASAI and KAZUTO HIRATA

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01989.x

      Alveolar nitric oxide concentration measured by the trumpet shape of the airway tree and axial diffusion model (CANO TMAD) reflects small airways obstruction more selectively than that measured by the two-compartment model (CANO 2CM). Measurement of CANO TMAD may clarify the role of the small airways in the pathogenesis of asthma.

  7. CORRESPONDENCE

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. Reference values for spirometry: The way forward for our patients (page 869)

      Sanja Stanojevic and Graham L. Hall

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01987.x

  8. FORTHCOMING MEETINGS

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. FORTHCOMING MEETINGS (page 870)

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01837_1.x

  9. JOURNAL STATISTICS

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES: CUTTING EDGE TECHNOLOGIES
    4. INVITED REVIEW SERIES: PLEURAL DISEASE
    5. INVITED REVIEW SERIES: RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    6. RESPIRATORY HEALTH ISSUES IN THE ASIA-PACIFIC REGION
    7. ORIGINAL ARTICLES
    8. CORRESPONDENCE
    9. FORTHCOMING MEETINGS
    10. JOURNAL STATISTICS
    1. JOURNAL STATISTICS (page 870)

      Article first published online: 28 JUN 2011 | DOI: 10.1111/j.1440-1843.2011.01837_2.x

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