Pleural fluid nucleic acid testing enhances pneumococcal surveillance in children (pages 114–119)
ROXANNE. E. STRACHAN, ANITA CORNELIUS, GWENDOLYN. L. GILBERT, TANYA GULLIVER, ANDREW MARTIN, TIM MCDONALD, GILLIAN NIXON, ROB ROSEBY, SARATH RANGANATHAN, HIRAN SELVADURAI, GREG SMITH, MANUEL SOTO-MARTINEZ, SADASIVAM SURESH, LAUREL TEOH, KIRAN THAPA, CLAIRE E. WAINWRIGHT and ADAM JAFFÉ
Article first published online: 21 DEC 2011 | DOI: 10.1111/j.1440-1843.2011.02035.x
National surveillance of invasive pneumococcal disease includes serotyping of Streptococcus pneumoniae isolates from positive sterile site cultures. The use of molecular techniques to identify and serotype S. pneumoniae in culture-negative specimens resulted in additional serotype information, complementing national surveillance data. This has important implications for monitoring serotype replacement following introduction of new vaccines.