Respirology

Cover image for Vol. 17 Issue 4

May 2012

Volume 17, Issue 4

Pages 585–737

  1. EDITORIALS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
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    2. You have free access to this content
  2. INVITED REVIEW SERIES

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Air Pollution and Lung Health

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      Genomics and the respiratory effects of air pollution exposure (pages 590–600)

      JOHN W. HOLLOWAY, SANTIYAGU SAVARIMUTHU FRANCIS, KWUN M. FONG and IAN A. YANG

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02164.x

    2. Obesity and Respiratory Disorders

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      Obesity hypoventilation syndrome: From sleep-disordered breathing to systemic comorbidities and the need to offer combined treatment strategies (pages 601–610)

      JEAN-CHRISTIAN BOREL, ANNE-LAURE BOREL, DENIS MONNERET, RENAUD TAMISIER, PATRICK LEVY and JEAN-LOUIS PEPIN

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2011.02106.x

    3. Translating Research into Practice

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      Clinical applications of lung function tests: A revisit (pages 611–619)

      BIN-MIAO LIANG, DAVID C.L. LAM and YU-LIN FENG

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02149.x

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      Biomarkers and transcriptome profiling of lung cancer (pages 620–626)

      HSUAN-YU CHEN, SUNG-LIANG YU, KER-CHAU LI and PAN-CHYR YANG

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02154.x

  3. REVIEW

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. You have free access to this content
      Treatments for anxiety and depression in patients with chronic obstructive pulmonary disease: A literature review (pages 627–638)

      PAUL A. CAFARELLA, TANJA W. EFFING, ZAFAR-AHMAD USMANI and PETER A. FRITH

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02148.x

  4. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Effects of budesonide/formoterol combination therapy versus budesonide alone on airway dimensions in asthma (pages 639–646)

      MAKOTO HOSHINO and JUNICHI OHTAWA

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02130.x

      The mechanism by which budesonide/formoterol combination therapy exerts clinically beneficial effects appears to be related to increased anti-inflammatory activity and attenuation of aspects of airway remodelling in asthmatic patients.

    2. The six-minute walk test using forehead oximetry is reliable in the assessment of scleroderma lung disease (pages 647–652)

      MARGARET WILSHER, NICOLA GOOD, RAEWYN HOPKINS, PAMELA YOUNG, DAVID MILNE, ANDREW GIBSON, RAVI SUPPIAH, JASON LY, ROBERT DOUGHTY and NICOLA DALBETH

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02133.x

      There were modest correlations between the six-minute walk test (6MWT), and CT or lung function parameters in patients with scleroderma. The novel finding of greater reliability of forehead compared with finger or earlobe oximetry is relevant to using 6MWD as a measure of disease progression or treatment response in scleroderma lung disease.

    3. The prevalence and predictors of airway hyperresponsiveness in sarcoidosis (pages 653–659)

      LISA M. YOUNG, NICHOLA GOOD, DAVID MILNE, IRENE ZENG, JOHN KOLBE and MARGARET L. WILSHER

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02137.x

      We found a higher prevalence of airway hyperresponsiveness (AHR) in patients with sarcoidosis using direct (histamine) challenge than indirect (hypertonic saline) challenge, and AHR was inversely associated with baseline % predicted FEV1. This suggests that AHR in sarcoidosis reflects the consequences of airway remodelling following inflammation.

    4. N-terminal proB-type natriuretic peptide levels aid the diagnosis of left ventricular dysfunction in patients with severe acute exacerbations of chronic obstructive pulmonary disease and renal dysfunction (pages 660–666)

      ISLEM OUANES, FATEN JALLOUL, SAMIA AYED, FAHMI DACHRAOUI, LAMIA OUANES-BESBES, MOHAMED FEKIH HASSEN, SOUHEIL ELATROUS and FEKRI ABROUG

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02153.x

      NT-proBNP levels were effective for the diagnosis of left ventricular dysfunction in patients with acute exacerbations of COPD. The diagnostic accuracy of NT-proBNP levels in the setting of impaired renal function was confirmed. Diagnosis thresholds were higher in patients with impaired renal function compared to those without.

    5. Reference values for airway resistance in newborns, infants and preschoolers from a Latin American population (pages 667–673)

      LAURA G. GOCHICOA, LAURA P. THOMÉ-ORTIZ, MARÍA E. Y. FURUYA, RAQUEL CANTO, MARTHA E. RUIZ-GARCÍA, GUILLERMO ZÚÑIGA-VÁZQUEZ, FILIBERTO MARTÍNEZ-RAMÍREZ and MARIO H. VARGAS

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02156.x

      There are no reference values for airway resistance measured by the interrupter technique (Rint) in Latin American newborns, infants and preschoolers. In this study of 264 children aged 24 days to 6.6 years, reference values for Rint applicable to Mexican children and those from other Latin American countries were determined.

    6. Pulmonary function vascular index predicts prognosis in idiopathic interstitial pneumonia (pages 674–680)

      TAMERA J. CORTE, STEPHEN J. WORT, PETER S. MACDONALD, ANTHONY EDEY, DAVID M. HANSELL, ELISABETTA RENZONI, TOBY M. MAHER, ANDREW G. NICHOLSON, STEVEN BANDULA, PAUL BRESSER and ATHOL U. WELLS

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2011.02121.x

      In patients with idiopathic interstitial pneumonia, baseline KCO (diffusing capacity adjusted for VA) and 6-month decline in KCO are both associated with increased early and overall mortality and, in a subgroup of patients with follow-up echocardiography, are associated with the development of pulmonary hypertension at follow-up.

    7. Outcome of Pneumocystis jirovecii pneumonia diagnosed by polymerase chain reaction in patients without human immunodeficiency virus infection (pages 681–686)

      EMILIA HARDAK, AMI NEUBERGER, MORDECHAI YIGLA, GIDON BERGER, RENATO FINKELSTEIN, HANNAH SPRECHER and ILANA OREN

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02158.x

      Pneumocystis pneumonia (PCP) is associated with a high mortality in HIV-negative patients. In this study, mortality among these patients was lower than that reported previously; this may be associated with the use of a PCR-based assay for the early diagnosis of PCP.

    8. Comparison of adherence between twice- and thrice-daily regimens of oral amoxicillin/clavulanic acid (pages 687–692)

      CARL LLOR, CAROLINA BAYONA, SILVIA HERNÁNDEZ, ANA MORAGAS and MARC MIRAVITLLES

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02159.x

      Compliance with amoxicillin/clavulanic acid therapy among patients with community-acquired infections was very low and was significantly lower among those using the standard thrice-daily formulation than among those using the new pharmacokinetically enhanced twice-daily formulation.

    9. Correlation between circulating fibrocytes, and activity and progression of interstitial lung diseases (pages 693–698)

      ATSUSHI FUJIWARA, HIROYASU KOBAYASHI, MASAHIRO MASUYA, MITSUKO MARUYAMA, SHIHO NAKAMURA, HIDENORI IBATA, HAJIME FUJIMOTO, MASAHIRO OHNISHI, MASAHITO URAWA, MASAHIRO NAITO, TAKEHIRO TAKAGI, TETSU KOBAYASHI, ESTEBAN C. GABAZZA, YOSHIYUKI TAKEI and OSAMU TAGUCHI

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02167.x

      Circulating fibrocytes may play a role in pulmonary fibrosis and clinical outcomes. This study demonstrated that high numbers of circulating fibrocytes correlated with pulmonary function test parameters and disease activity in patients with different interstitial lung diseases. It provides further support for the potential role of fibrocytes in pulmonary fibrosis.

    10. Replication of results of genome-wide association studies on lung cancer susceptibility loci in a Korean population (pages 699–706)

      EUN YOUNG BAE, SHIN YUP LEE, BONG KYOON KANG, EUN JIN LEE, YI YOUNG CHOI, HYO-GYOUNG KANG, JIN EUN CHOI, HYO-SUNG JEON, WON KEE LEE, SHIN KAM, KYUNG MIN SHIN, GUANG JIN, SEUNG SOO YOO, JAEHEE LEE, SEUNG ICK CHA, CHANG HO KIM, TAE HOON JUNG and JAE YONG PARK

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02165.x

      The results of genome-wide association studies on lung cancer susceptibility were replicated in a Korean population. The associations between SNP in the 5p15 and 15q25 chromosomal regions and lung cancer risk were confirmed, providing credible evidence that these genetic variants influence susceptibility to lung cancer.

    11. Effect of an integrated care programme on re-hospitalization of patients with chronic obstructive pulmonary disease (pages 707–714)

      GRÉGORY MOULLEC, KIM L. LAVOIE, KHALIL RABHI, MARCEL JULIEN, HÉLÈNE FAVREAU (c) and MANON LABRECQUE

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02168.x

      A 1-year integrated care programme with two components (patient-centred education + case management) was evaluated for its effectiveness in preventing COPD-related hospitalizations, and whether this was comparable for men and women. This study is the first to demonstrate that women benefited more from such an integrated care intervention.

    12. Intravenous diuretic and vasodilator therapy reduce plasma brain natriuretic peptide levels in acute exacerbation of chronic obstructive pulmonary disease (pages 715–720)

      JUN ZHANG, GUANGDAN ZHAO, XIAOLING YU and XIAOMING PAN

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02162.x

      Plasma brain natriuretic peptide levels decreased rapidly in patients with acute exacerbations of chronic obstructive pulmonary disease after intravenous therapy with a diuretic and a vasodilator, and the treatment did not impair the health status of these patients.

    13. Solving the Light's criteria misclassification rate of cardiac and hepatic transudates (pages 721–726)

      SILVIA BIELSA, JOSÉ M. PORCEL, JOSÉ CASTELLOTE, ESTELA MAS, AURELI ESQUERDA and RICHARD W. LIGHT

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02155.x

      Contrary to common belief, the albumin gradient performs significantly better than the protein gradient to correctly classify ‘false’ exudates of cardiac origin. In contrast, in patients with cirrhosis whose pleural fluid meets Light's exudative criteria, the use of the albumin ratio is preferred.

    14. Low-dose clarithromycin therapy modulates CD4+ T-cell responses in a mouse model of chronic Pseudomonas aeruginosa lung infection (pages 727–734)

      FENG-MING DING, SONG-LEI ZHU, CE SHEN and YAN-QUN JIANG

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02166.x

      The effects of low-dose clarithromycin therapy on CD4+ T-cell responses were investigated in mice with chronic Pseudomonas aeruginosa lung infection. Th1/Th17 and naturally occurring regulatory T responses were downregulated, which might contribute to the anti-inflammatory effects of low-dose clarithromycin therapy.

  5. SCIENTIFIC LETTER

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Compliance with home non-invasive ventilation (pages 735–736)

      SUET-LAI CHENG, VERONICA L. CHAN and CHUNG-MING CHU

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02169.x

  6. FORTHCOMING MEETINGS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. FORTHCOMING MEETINGS (page 737)

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02042.x

  7. JOURNAL STATISTICS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTER
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. JOURNAL STATISTICS (page 737)

      Article first published online: 19 APR 2012 | DOI: 10.1111/j.1440-1843.2012.02042_2.x

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