Jiaying Luo and Sichang Xiao contributed equally to this work.
Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea
Article first published online: 21 MAR 2013
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology
Volume 18, Issue 3, pages 528–533, April 2013
How to Cite
Luo, J., Xiao, S., Qiu, Z., Song, N. and Luo, Y. (2013), Comparison of manual versus automatic continuous positive airway pressure titration and the development of a predictive equation for therapeutic continuous positive airway pressure in Chinese patients with obstructive sleep apnoea. Respirology, 18: 528–533. doi: 10.1111/resp.12014
Associate Editor: Amanda Piper
- Issue published online: 21 MAR 2013
- Article first published online: 21 MAR 2013
- Accepted manuscript online: 12 NOV 2012 07:00AM EST
- Manuscript Accepted: 3 OCT 2012
- Manuscript Revised: 26 SEP 2012
- Manuscript Received: 17 JUL 2012
- National Nature Science Foundation of China. Grant Number: 81120108001
- automatic titration;
- continuous positive airway pressure;
- manual titration;
- obstructive sleep apnoea;
Background and objective
Whether the therapeutic nasal continuous positive airway pressure (CPAP) derived from manual titration is the same as derived from automatic titration is controversial. The purpose of this study was to compare the therapeutic pressure derived from manual titration with automatic titration.
Fifty-one patients with obstructive sleep apnoea (OSA) (mean apnoea/hypopnoea index (AHI) = 50.6 ± 18.6 events/h) who were newly diagnosed after an overnight full polysomnography and who were willing to accept CPAP as a long-term treatment were recruited for the study. Manual titration during full polysomnography monitoring and unattended automatic titration with an automatic CPAP device (REMstar Auto) were performed. A separate cohort study of one hundred patients with OSA (AHI = 54.3 ± 18.9 events/h) was also performed by observing the efficacy of CPAP derived from manual titration.
The treatment pressure derived from automatic titration (9.8 ± 2.2 cmH2O) was significantly higher than that derived from manual titration (7.3 ± 1.5 cmH2O; P < 0.001) in 51 patients. The cohort study of 100 patients showed that AHI was satisfactorily decreased after CPAP treatment using a pressure derived from manual titration (54.3 ± 18.9 events/h before treatment and 3.3 ± 1.7 events/h after treatment; P < 0.001).
The results suggest that automatic titration pressure derived from REMstar Auto is usually higher than the pressure derived from manual titration.