The Authors: Associate Professor Ivan Bertoncello is the head of the Lung Regeneration Laboratory leading research investigating the organization and regulation of adult lung stem and progenitor cells, and their role in lung regeneration and repair. Dr Jonathan McQualter leads the Lung Stem Cells and Microenvironment Group and has a strong interest in understanding how the dynamic interaction of lung epithelial stem cells with their microenvironment regulates their regenerative potential.
INVITED REVIEW SERIES: STEM CELLS AND THE LUNG
Lung stem cells: Do they exist?
Version of Record online: 25 APR 2013
© 2013 The Authors. Respirology © 2013 Asian Pacific Society of Respirology
Volume 18, Issue 4, pages 587–595, May 2013
How to Cite
Bertoncello, I. and McQualter, J. L. (2013), Lung stem cells: Do they exist?. Respirology, 18: 587–595. doi: 10.1111/resp.12073
SERIES EDITORS: YUBEN MOODLEY AND PHILIP J THOMPSON
- Issue online: 25 APR 2013
- Version of Record online: 25 APR 2013
- Accepted manuscript online: 22 FEB 2013 02:35AM EST
- Manuscript Accepted: 7 FEB 2013
- Manuscript Revised: 1 FEB 2013
- Manuscript Received: 24 JAN 2013
- Australian National Health and Medical Research Council. Grant Number: 1009374
- Victorian Cancer Agency
- adult stem cell;
- airway epithelium;
- animal model;
- cell biology;
- lung regeneration
Recognition of the potential of stem cell-based therapies for alleviating intractable lung diseases has provided the impetus for research aimed at identifying regenerative cells in the adult lung, understanding how they are organized and regulated, and how they could be harnessed in lung regenerative medicine. In this review, we describe the attributes of adult stem and progenitor cells in adult organs and how they are regulated by the permissive or restrictive microenvironment in which they reside. We describe the power and limitations of experimental models, cell separative strategies and functional assays used to model the organization and regulation of adult airway and alveolar stem cells in the adult lung. The review summarizes recent progress and obstacles in defining endogenous lung epithelial stem and progenitor cells in mouse models and in translational studies.