• 1
    World Health Organization. The global burden of disease: 2004 update. 2008. [Accessed 18 May 2013.] Available from URL:
  • 2
    Global Initiative for Chronic Obstructive Lung Disease. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. Revised 2011. [Accessed 15 Jun 2013.] Available from URL:
  • 3
    Wan ES, Silverman EK. Genetics of COPD and emphysema. Chest 2009; 136: 859866.
  • 4
    Salvi SS, Barnes PJ. Chronic obstructive pulmonary disease in non-smokers. Lancet 2009; 374: 733743.
  • 5
    Madison JM, Irwin RS. Chronic obstructive pulmonary disease. Lancet 1998; 352: 467473.
  • 6
    Peat JK, Woolcock AJ, Cullen K. Decline of lung function and development of chronic airflow limitation: a longitudinal study of non-smokers and smokers in Busselton, Western Australia. Thorax 1990; 45: 3237.
  • 7
    Hopkinson NS, Polkey MI. Does physical inactivity cause chronic obstructive pulmonary disease? Clin Sci (Lond) 2010; 118: 565572.
  • 8
    Shaheen SO, Jameson KA, Syddall HE, Sayer AA, Dennison EM, Cooper C, Robinson SM. The relation of dietary patterns with adult lung function and COPD. Eur. Respir. J. 2010; 36: 277284.
  • 9
    Varraso R, Fung TT, Hu FB, Willett W, Camargo CA. Prospective study of dietary patterns and chronic obstructive pulmonary disease among US men. Thorax 2007; 62: 786791.
  • 10
    Galisteo M, Duarte J, Zarzuelo A. Effects of dietary fibers on disturbances clustered in the metabolic syndrome. J. Nutr. Biochem. 2008; 19: 7184.
  • 11
    Kaczmarczyk MM, Miller MJ, Freund GG. The health benefits of dietary fiber: beyond the usual suspects of type 2 diabetes mellitus, cardiovascular disease and colon cancer. Metabolism 2012; 61: 10581066.
  • 12
    Maslowski KM, Mackay CR. Diet, gut microbiota and immune responses. Nat. Immunol. 2011; 12: 59.
  • 13
    Wall R, Ross RP, Fitzgerald GF, Stanton C. Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids. Nutr. Rev. 2010; 68: 280289.
  • 14
    Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000; 283: 20082012.
  • 15
    Kan H, Stevens J, Heiss G, Rose KM, London SJ. Dietary fiber, lung function, and chronic obstructive pulmonary disease in the atherosclerosis risk in communities study. Am. J. Epidemiol. 2008; 167: 570578.
  • 16
    Hirayama F, Lee AH, Binns CW, Zhao Y, Hiramatsu T, Tanikawa Y, Nishimura K, Taniguchi H. Do vegetables and fruits reduce the risk of chronic obstructive pulmonary disease? A case-control study in Japan. Prev. Med. 2009; 49: 184189.
  • 17
    Butler LM, Koh WP, Lee HP, Yu MC, London SJ. Dietary fiber and reduced cough with phlegm: a cohort study in Singapore. Am. J. Respir. Crit. Care Med. 2004; 170: 279287.
  • 18
    Varraso R, Willett WC, Camargo CA Jr. Prospective study of dietary fiber and risk of chronic obstructive pulmonary disease among US women and men. Am. J. Epidemiol. 2010; 171: 776784.
  • 19
    Hirayama F, Lee AH, Binns CW, Hiramatsu N, Mori M, Nishimura K. Dietary intake of isoflavones and polyunsaturated fatty acids associated with lung function, breathlessness and the prevalence of chronic obstructive pulmonary disease: possible protective effect of traditional Japanese diet. Mol. Nutr. Food Res. 2010; 54: 909917.
  • 20
    Shahar E, Folsom AR, Melnick SL, Tockman MS, Comstock GW, Gennaro V, Higgins MW, Sorlie PD, Ko WJ, Szklo M. Dietary n-3 polyunsaturated fatty acids and smoking-related chronic obstructive pulmonary disease. Atherosclerosis Risk in communities study investigators. N. Engl. J. Med. 1994; 331: 228233.
  • 21
    McKeever TM, Lewis SA, Cassano PA, Ocke M, Burney P, Britton J, Smit HA. The relation between dietary intake of individual fatty acids, FEV1 and respiratory disease in Dutch adults. Thorax 2008; 63: 208214.
  • 22
    Wood LG, Attia J, McElduff P, McEvoy M, Gibson PG. Assessment of dietary fat intake and innate immune activation as risk factors for impaired lung function. Eur. J. Clin. Nutr. 2010; 64: 818825.
  • 23
    Schwartz J, Weiss ST. Dietary factors and their relation to respiratory symptoms. The Second National Health and Nutrition Examination Survey. Am. J. Epidemiol. 1990; 132: 6776.
  • 24
    European Food Safety Authority. Panel on dietetic products, nutrition & allergies. Scientific opinion on dietary reference values for carbohydrates and dietary fibre. EFSA J. 2010; 8: 14621539.
  • 25
    Clini E, Crisafulli E, Radaeli A, Malerba M. COPD and the metabolic syndrome: an intriguing association. Intern. Emerg. Med. 2013; 8: 283289.
  • 26
    Keranis E, Makris D, Rodopoulou P, Martinou H, Papamakarios G, Daniil Z, Zintzaras E, Gourgoulianis KI. Impact of dietary shift to higher-antioxidant foods in COPD: a randomised trial. Eur. Respir. J. 2010; 36: 774780.
  • 27
    Baldrick FR, Elborn JS, Woodside JV, Treacy K, Bradley JM, Patterson CC, Schock BC, Ennis M, Young IS, McKinley MC. Effect of fruit and vegetable intake on oxidative stress and inflammation in COPD: a randomised controlled trial. Eur. Respir. J. 2012; 39: 13771384.
  • 28
    Lee PN, Fry JS. Systematic review of the evidence relating FEV1 decline to giving up smoking. BMC Med. 2010; 8: 84.
  • 29
    Omori H, Nonami Y, Morimoto Y. Effect of smoking on FEV decline in a cross-sectional and longitudinal study of a large cohort of Japanese males. Respirology 2005; 10: 464469.
  • 30
    Theuwissen E, Mensink RP. Water-soluble dietary fibers and cardiovascular disease. Physiol. Behav. 2008; 94: 285292.
  • 31
    de Batlle J, Sauleda J, Balcells E, Gomez FP, Mendez M, Rodriguez E, Barreiro E, Ferrer JJ, Romieu I, Gea J et al. Association between Omega3 and Omega6 fatty acid intakes and serum inflammatory markers in COPD. J. Nutr. Biochem. 2012; 23: 817821.
  • 32
    Food and Nutrition Board IoM. Dietary Reference Intakes for Carbohydrate, Fiber, Fat, Fatty Acids, Cholesterol, Protein, and Amino Acid. National Academies Press, Washington, DC, 2005.
  • 33
    Simopoulos AP. The importance of the omega-6/omega-3 fatty acid ratio in cardiovascular disease and other chronic diseases. Exp. Biol. Med. (Maywood) 2008; 233: 674688.
  • 34
    Novgorodtseva TP, Denisenko YK, Zhukova NV, Antonyuk MV, Knyshova VV, Gvozdenko TA. Modification of the fatty acid composition of the erythrocyte membrane in patients with chronic respiratory diseases. Lipids Health Dis. 2013; 12: 117.
  • 35
    Shahar E, Boland LL, Folsom AR, Tockman MS, McGovern PG, Eckfeldt JH. Docosahexaenoic acid and smoking-related chronic obstructive pulmonary disease. The Atherosclerosis Risk in Communities Study Investigators. Am. J. Respir. Crit. Care Med. 1999; 159: 17801785.
  • 36
    Kompauer I, Demmelmair H, Koletzko B, Bolte G, Linseisen J, Heinrich J. Association of fatty acids in serum phospholipids with lung function and bronchial hyperresponsiveness in adults. Eur. J. Epidemiol. 2008; 23: 175190.
  • 37
    Broekhuizen R, Wouters EF, Creutzberg EC, Weling-Scheepers CA, Schols AM. Polyunsaturated fatty acids improve exercise capacity in chronic obstructive pulmonary disease. Thorax 2005; 60: 376382.
  • 38
    Jans A, Konings E, Goossens GH, Bouwman FG, Moors CC, Boekschoten MV, Afman LA, Müller M, Mariman EC, Blaak E. PUFAs acutely affect triacylglycerol-derived skeletal muscle fatty acid uptake and increase postprandial insulin sensitivity. Am. J. Clin. Nutr. 2012; 95: 825836.