Conflict of interest: BJP has acted as a paid consultant to Faust Pharmaceuticals Inc. and has received funding for research carried out in this work.
Influence of changes in physical activity on frequency of hospitalization in chronic obstructive pulmonary disease
Version of Record online: 2 FEB 2014
© 2014 The Authors. Respirology © 2014 Asian Pacific Society of Respirology
Volume 19, Issue 3, pages 330–338, April 2014
How to Cite
Esteban, C., Arostegui, I., Aburto, M., Moraza, J., Quintana, J. M., Aizpiri, S., Basualdo, L. V. and Capelastegui, A. (2014), Influence of changes in physical activity on frequency of hospitalization in chronic obstructive pulmonary disease. Respirology, 19: 330–338. doi: 10.1111/resp.12239
(Associate Editor: Shu Hashimoto).
- Issue online: 12 MAR 2014
- Version of Record online: 2 FEB 2014
- Manuscript Accepted: 25 OCT 2013
- Manuscript Revised: 31 JUL 2013
- Manuscript Revised: 2 JUN 2013
- Manuscript Received: 14 APR 2013
- Fondo de Investigación Sanitaria. Grant Number: PI020510
- Departamento de Salud del Gobierno Vasco. Grant Numbers: 200111002, 2005111008, 2012111008
- Research Committee Hospital Galdakao-Usansolo
- Universidad del País Vasco UPV/EHU. Grant Number: UFI11/52
- Departamento de Educación, Política Lingüística y Cultura del Gobierno Vasco. Grant Number: IT620-13
- chronic obstructive pulmonary disease;
- physical activity.
Background and objective
To evaluate whether changes in regular physical activity (PA) in patients with chronic obstructive pulmonary disease (COPD) affect the rate of hospitalizations for COPD exacerbation (eCOPD).
Five hundred forty-three ambulatory clinic patients being treated for COPD were prospectively identified. PA was self-reported by patients, and the level was established by the distance they walked (km/day) at least 3 days per week. Hospitalizations were recorded from hospital databases. All patients with at least a 2-year follow-up after enrolment were included in the analysis. The response variable was the number of hospitalizations for eCOPD within the 3-year period from 2 to 5 years after study enrolment.
Three hundred ninety-one survivors were studied. Mean forced expiratory volume in 1 s was 52% (±14%) of the predicted value. Patients who maintained a lower level of PA had an increased rate of hospitalization (odds ratio 1.901; 95% confidence interval 1.090–3.317). After having had the highest level of PA, those patients who decreased their PA in the follow-up showed an increasing rate of hospitalizations (odds ratio 2.134; 95% confidence interval 1.146–3.977).
Patients with COPD with a low level of PA or who reduced their PA over time were more likely to experience a significant increase in the rate of hospitalization for eCOPD. Changes to a higher level of PA or maintaining a moderate or high level of PA over time, with a low intensity activity such as walking for at least 3–6 km/day, could reduce the rate of hospitalizations for eCOPD.