Respirology

Cover image for Vol. 18 Issue 4

May 2013

Volume 18, Issue 4

Pages 585–736

  1. EDITORIAL

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
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  2. INVITED REVIEW SERIES

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. Stem Cells and the Lung

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      Lung stem cells: Do they exist? (pages 587–595)

      Ivan Bertoncello and Jonathan L. McQualter

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12073

    2. Tuberculosis: Current State of Knowledge

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      Challenges to the global control of tuberculosis (pages 596–604)

      Chen-Yuan Chiang, Catharina Van Weezenbeek, Toru Mori and Donald A. Enarson

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12067

  3. INVITED REVIEW

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
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      Ambulatory models of care for obstructive sleep apnoea: Diagnosis and management (pages 605–615)

      Ching Li Chai-Coetzer, Nick A. Antic and R. Doug McEvoy

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12071

  4. REVIEW

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. You have free access to this content
  5. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. Predictors of outcome in patients with cystic fibrosis requiring endotracheal intubation (pages 630–636)

      Andrew Jones, Diana Bilton, Timothy W. Evans and Simon J. Finney

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12051

      Factors influencing survival in patients with CF undergoing mechanical ventilation were examined. Admissions following pneumothorax or haemoptysis had better outcomes than those following an infective disease exacerbation. Falling body mass index and osteoporosis were adverse prognostic factors. Neither previous FEV1 decline nor rate of hospitalization was associated with lower survival.

    2. Classification of broncholiths and clinical outcomes (pages 637–642)

      So Y. Lim, Kyung J. Lee, Kyeongman Jeon, Won-Jung Koh, Gee Y. Suh, Man P. Chung, Hojoong Kim, O Jung Kwon and Sang-Won Um

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12060

      We evaluated effective treatments of broncholithiasis. The broncholiths were classified as intraluminal, mixed and extraluminal. Intraluminal broncholiths can be removed via bronchoscopy, while surgery should be considered for symptomatic mixed or extraluminal broncholiths. The treatment of broncholithiasis should be based on chest CT and bronchoscopic findings.

    3. Increased claudin-3, -4 and -18 levels in bronchoalveolar lavage fluid reflect severity of acute lung injury (pages 643–651)

      Wenting Jin, Linyi Rong, Yinkun Liu, Yuanlin Song, Yan Li and Jue Pan

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12034

      Claudins, tight junction proteins, are key components of neighbouring epithelial and endothelial cell membranes, and regulate paracellular permeability. The novel finding that the claudin-3, -4, -18 levels in BALF are positively correlated with ALI severity suggest that claudins may be a potential biomarker to reflect lung injury severity.

    4. Physiotherapy for cystic fibrosis in Australia: Knowledge and acceptance of the Consensus Statement recommendations (pages 652–656)

      Anne E. Holland, Brenda M. Button and on behalf of the International Physiotherapy Group for Cystic Fibrosis, Australian Chapter

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12032

      This study tested the awareness and uptake of recommendations for physiotherapy management of CF in Australia. Awareness of recommendations was generally high, especially in core areas of physiotherapy practice. However, awareness and uptake was lower outside of major CF centres and in specialist areas of CF practice.

    5. Pentraxin-3: A novel biomarker for discriminating parapneumonic from other exudative effusions (pages 657–662)

      Savas Ozsu, Yasin Abul, Ahmet Mentese, Hayriye Bektas, Aysegul Uzun, Tevfik Ozlu and José M. Porcel

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12038

      PTX-3 is a relatively new marker of inflammation that has not been previously tested in pleural effusions. Here, we show that PTX-3 concentrations in pleural effusions may be helpful in distinguishing PPE from non-PPE. Its usefulness in differentiating simple from CPPE awaits further studies.

    6. Short-acting anticholinergic bronchodilation does not increase cardiovascular events in smokers with mild to moderate pulmonary obstruction (pages 663–668)

      Emmy de Jong, Wouter D. van Dijk, Yvonne Heijdra, Jacques W. M. Lenders, Chris van Weel, Reinier Akkermans and Tjard R. J. Schermer

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12040

      We hypothesized that short-acting anticholinergic bronchodilation increases cardiovascular morbidity and mortality in COPD patients that continue smoking. Our results reveal that in patients with mild to moderate airflow limitation, anticholinergic bronchodilation in addition to smoking has no additional detrimental effect on cardiovascular disease.

    7. Transbronchial cryo-biopsy in lung transplantation patients: First report (pages 669–673)

      Oren Fruchter, Ludmila Fridel, Dror Rosengarten, Yael Raviv, Viktoria Rosanov and Mordechai R. Kramer

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12037

      Forty lung transplantation patients underwent cryo-TBB. Cryo-biopsies provide larger and more diagnostic lung parenchyma specimens with lower complication rate than traditional forceps biopsies.

    8. Leukotriene C4 aggravates bleomycin-induced pulmonary fibrosis in mice (pages 674–681)

      Hirokuni Hirata, Masafumi Arima, Yasutsugu Fukushima, Kumiya Sugiyama, Takeshi Tokuhisa and Takeshi Fukuda

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12072

      Bleomycin-induced pulmonary fibrosis is augmented in LTC4 transgenic mice. LTC4 overexpression was associated with more fibrosis and higher lavage levels of IL-4, IL-13 and TGF-β1.

    9. Relationship between bronchial hyperresponsiveness and lung function in children age 5 and 6 with and without asthma (pages 682–687)

      Satoru Takami, Hiroyuki Mochizuki, Reiko Muramatsu, Satomi Hagiwara and Hirokazu Arakawa

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12061

      We investigated the relationship between bronchial hyperresponsiveness and lung function in asthmatic, non-asthmatic wheezer and healthy children while minimizing the effects of age and height. No significant differences between asthmatics and non-asthmatic wheezers in bronchial sensitivity were observed. Bronchial reactivity was strongly correlated with the baseline respiratory resistance.

    10. A possible role for CD8+ and non-CD8+ cell granzyme B in early small airway wall remodelling in centrilobular emphysema (pages 688–696)

      Won-Dong Kim, Hyun-Sook Chi, Kang-Hyeon Choe, Yeon-Mok Oh, Sang-Do Lee, Kyu-Rae Kim, Kwang-Ha Yoo, David A. Ngan, W. Mark Elliott, David J. Granville, Don D. Sin and James C. Hogg

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12069

      This study shows that granzyme B is expressed in CD8+ T cells, monocytes and granulocytes in small airway walls in centrilobular emphysema, where monocytes expressing both granzyme B and macrophage scavenger receptor are also identified. These granzyme B-positive cells may play an important role in early small airway wall remodelling.

    11. X-linked inhibitor of apoptosis single nucleotide polymorphisms and copy number variation are not risk factors for asthma (pages 697–703)

      Eugene Roscioli, Rhys Hamon, Richard E. Ruffin, Peter Zalewski, Janet Grant and Susan Lester

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12065

      Altered regulation of apoptosis contributes to the pathophysiology of asthma. The XIAP encoded by BIRC4 inhibits caspase function, apoptosis and participates in signalling events involved in the inflammatory response. However, BIRC4 SNPs and CNV do not associate with the disease.

    12. Rigid versus semi-rigid thoracoscopy for the diagnosis of pleural disease: A randomized pilot study (pages 704–710)

      Ales Rozman, Luka Camlek, Mateja Marc-Malovrh, Nadja Triller and Izidor Kern

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12066

      Semi-rigid and rigid thoracoscopy were compared in a prospective, randomized clinical trial. Biopsy specimens, obtained by semi-rigid technique were smaller, but of comparable quality. There were no differences in interpretability between both groups as assessed by pathologist, blinded for the technique used. Diagnostic yields of both techniques were comparable.

    13. Low prostaglandin E2 and cyclooxygenase expression in nasal mucosa fibroblasts of aspirin-intolerant asthmatics (pages 711–717)

      Jordi Roca-Ferrer, Maria Pérez-Gonzalez, Francesc J. Garcia-Garcia, Javier Pereda, Laura Pujols, Isam Alobid, Joaquim Mullol and Cesar Picado

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12076

      We demonstrate that the role of cyclooxygenase enzymes in arachidonic acid metabolism is altered in the nasal mucosa of aspirin-intolerant asthmatic patients. This suggests that abnormalities in cyclooxygenase enzymes are present in all the nasal mucosa of these patients. Our results provide further support to the consensus term of rhinosinusitis.

    14. Effect of health professional education on outcomes of chronic obstructive pulmonary disease in primary care: A non randomized clinical trial (pages 718–727)

      Mònica Monteagudo, Teresa Rodriguez-Blanco, Maria Llagostera, Carles Valero, Xavier Bayona, Sílvia Granollers, Juan J. Ferro, Mateo Acedo, Jesús Almeda, Lluisa Rodriguez-Latre, Laura Muñoz and Marc Miravitlles

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12074

      We describe the implementation of an education programme in a primary care setting to improve the quality of life of COPD patients, which we were not able to improve. We achieved improvement in dietary, exercise and smoking habits but no reduced exacerbation rates or hospital admissions were documented after 12 months.

    15. Peptic ulceration, Helicobacter pylori seropositivity and chronic obstructive pulmonary disease (pages 728–731)

      Roshan Siva, Surinder S. Birring, Michael Berry, Anita Rowbottom and Ian D. Pavord

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12075

      Prior peptic ulcer disease was related to COPD severity in miners from Nottinghamshire. H. Pylori serology was positive in a significantly higher proportion of patients with COPD compared with a control population. These findings raise the possibility of a causal link between H. Pylori infection, peptic ulcer disease and COPD.

  6. SCIENTIFIC LETTERS

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. Chronic cough management: Dealing with a sensation of mucus in the throat (pages 732–733)

      Haruhiko Ogawa, Masaki Fujimura, Yasuo Takeuchi and Koichi Makimura

      Version of Record online: 25 APR 2013 | DOI: 10.1111/resp.12064

  7. FORTHCOMING MEETINGS

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. You have free access to this content
      Forthcoming Meetings (page 736)

      Version of Record online: 25 APR 2013 | DOI: 10.1111/j.1440-1843.2013.02236.x

  8. JOURNAL STATISTICS

    1. Top of page
    2. EDITORIAL
    3. INVITED REVIEW SERIES
    4. INVITED REVIEW
    5. REVIEW
    6. ORIGINAL ARTICLES
    7. SCIENTIFIC LETTERS
    8. FORTHCOMING MEETINGS
    9. JOURNAL STATISTICS
    1. You have free access to this content
      Journal Statistics (page 736)

      Version of Record online: 25 APR 2013 | DOI: 10.1111/j.1440-1843.2013.02236_2.x

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