Respirology

Cover image for Vol. 18 Issue 8

November 2013

Volume 18, Issue 8

Pages 1161–1282

  1. EDITORIALS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
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    2. You have free access to this content
    3. You have free access to this content
  2. INVITED REVIEW SERIES

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Stem Cells and The Lung

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      Stem cells: A recapitulation of development (pages 1167–1176)

      Yuben Moodley, Philip Thompson and David Warburton

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12186

  3. REVIEW

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. You have free access to this content
  4. ORIGINAL ARTICLES

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Cardiovascular mortality in obstructive sleep apnoea treated with continuous positive airway pressure or oral appliance: An observational study (pages 1184–1190)

      Anil Anandam, Monali Patil, Morohunfolu Akinnusi, Philippe Jaoude and Ali A. El-Solh

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12140

      This study suggests for the first time that oral appliances may confer reduction in cardiovascular mortality for patients with severe obstructive sleep apnoea intolerant to continuous positive airway pressure.

    2. Smoking-related emphysema is associated with idiopathic pulmonary fibrosis and rheumatoid lung (pages 1191–1196)

      Katerina M. Antoniou, Simon L. Walsh, David M. Hansell, Michael R. Rubens, Katharina Marten, Rachel Tennant, Trevor Hansel, Sujal R. Desai, Nikolaos M. Siafakas, Roland M du Bois and Athol U. Wells

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12154

      There is a high prevalence of smoking-related emphysema in IPF and rheumatoid lung, often associated with a low pack-year smoking history. Fibrotic abnormalities on HRCT are coarser in smokers with both disorders. These observations raise the possibility of shared mechanisms between fibrogenesis and smoking-related damage.

    3. Fluticasone uptake across Calu-3 cells is mediated by salmeterol when deposited as a combination powder inhaler (pages 1197–1201)

      Mehra Haghi, Daniela Traini, Dirkje S. Postma, Mary Bebawy and Paul M. Young

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12146

      This study shows for the first time that salmeterol prolongs the transport of fluticasone across the epithelial cell layer following codeposition of salmeterol and fluticasone particles on epithelial cell cultures. This may increase residence time of fluticasone in the airways and result in prolonged anti-inflammatory effects of this corticosteroid.

    4. Genetic variants in HHIP are associated with FEV1 in subjects with chronic obstructive pulmonary disease (pages 1202–1209)

      Woo Jin Kim, Yeon-Mok Oh, Jin Hwa Lee, Choon-Sik Park, Sung Woo Park, Jong Sook Park and Sang Do Lee

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12139

      Association of HHIP and COPD were mostly reported in Caucasians, and additional studies in multiple ethnic groups are needed. We investigated genetic associations of HHIP in Korean COPD and control subjects. Genetic variants in HHIP were associated with lung function in subjects with COPD.

    5. Positive blood culture is not associated with increased mortality in patients with sepsis-induced acute respiratory distress syndrome (pages 1210–1216)

      Szu-Chun Yang, Kuang-Ming Liao, Chang-Wen Chen and Wei-Chieh Lin

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12121

      We evaluated the relationship between positive blood culture and the outcomes of sepsis-induced ARDS. We found that positive blood culture was not associated with increased mortality. However, the mean durations of hospital and intensive care unit stays in patients with sepsis-induced ARDS were increased.

    6. Effect of nutritional status in individuals with chronic obstructive pulmonary disease undergoing pulmonary rehabilitation (pages 1217–1222)

      Ersin Günay, Dicle Kaymaz, Nursel Türkoglu Selçuk, Pinar Ergün, Fatma Sengül and Nese Demir

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12133

      Evaluation of nutritional status of patients with COPD is often overlooked and neglected in clinical practice. We found that the subjective global assessment may be used as a convenient and practical tool to evaluate nutritional status, an important component of pulmonary rehabilitation, and to understand whether supportive therapy is required.

    7. Effect of salbutamol on the measurement of single-breath diffusing capacity (pages 1223–1229)

      Jun Yang, Josh Stanton, Lexin Wang, Lutz Beckert, Chris Frampton, Debbie Burton and Maureen P. Swanney

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12125

      The effect of salbutamol on DL,CO was investigated in subjects with and without airway obstruction and reversibility. The findings suggest that salbutamol may considerably reduce DL,CO in some individuals with reversible airway disease secondary to its effects on VA and KCO.

    8. Effect of granulocyte-macrophage colony-stimulating factor on neutrophil function in idiopathic bronchiectasis (pages 1230–1235)

      Marie-Hélène Ruchaud-Sparagano, Helen Gertig, Katy L.M. Hester, James G. Macfarlane, Paul A. Corris, A. John Simpson and Anthony De Soyza

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12138

      This study assessed the function of PBN in non-cystic fibrosis bronchiectasis. Phagocytosis and superoxide generation were preserved in bronchiectasis, and both were augmented by GM-CSF.

    9. Clinical significance of serum hyaluronan in chronic fibrotic interstitial pneumonia (pages 1236–1243)

      Yayoi Inokoshi, Yoshinori Tanino, Xintao Wang, Suguru Sato, Naoko Fukuhara, Takefumi Nikaido, Atsuro Fukuhara, Junpei Saito, Charles W. Frevert and Mitsuru Munakata

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12144

      Although extracellular matrix proteins such as hyaluronan have been thought to be a little more than a simple ‘glue’ in the interstitium of the lung, this study suggests that serum hyaluronan may be a clinically useful biomarker of interstitial pneumonia.

    10. Mean platelet volume is decreased during an acute exacerbation of chronic obstructive pulmonary disease (pages 1244–1248)

      Rui-tao Wang, Jia-Ying Li, Zhi-gang Cao and Ying Li

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12143

      The study investigates MPV in patients with stable COPD. MPV is reduced in stable COPD compared with controls. The MPV decreased further in acute exacerbation.

    11. Inhibition of interleukin-13 gene expression by triptolide in activated T lymphocytes (pages 1249–1255)

      Shanlin Dai, Kaisheng Yin, Xin Yao and Lin Zhou

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12145

      This study demonstrated that triptolide, an anti-asthma drug from traditional Chinese medicine, could inhibit IL-13 gene transcription and protein expression in activated T cells by inhibiting the nuclear translocation of GATA3 and NFAT1, and decreasing the association of IL-13 gene promoter region with GATA3 or NFAT1.

    12. Risk factors for respiratory symptoms in adults: The Busselton Health Study (pages 1256–1260)

      Alan L. James, Matthew W. Knuiman, Mark L. Divitini, Jennie Hui, Michael L. Hunter, Siobhain A. Mulrennan and A. W. ‘Bill’ Musk

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12147

      This study analysed population data to determine the relationships between environmental exposures and respiratory symptoms that may contribute to reported wheeze or cough/phlegm in adults. It found that these symptoms have independent determinants and that diagnostic transfer may contribute to an observed increase in reported asthma in adults.

    13. Molecular diagnostic algorithm for epidermal growth factor receptor mutation detection in Asian lung adenocarcinomas: Comprehensive analyses of 445 Taiwanese patients with immunohistochemistry, PCR-direct sequencing and Scorpion/ARMS methods (pages 1261–1270)

      Hsiang-Ling Ho, Fu-Pang Chang, Hsiu-Hsun Ma, Li-Rung Liao, Yu-Ting Chuang, Yi-Chun Chang-Chien, Kun-Yang Lin and Teh-Ying Chou

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12148

      Four hundred forty-five lung adenocarcinoma patients were enrolled for analysis of tumour epidermal growth factor receptor (EGFR) mutation status using polymerase chain reaction/direct sequencing, immunohistochemistry and Scorpion/amplified refractory mutation system technology. An algorithm for comprehensive and efficient testing of EGFR mutations on lung adenocarcinoma patients in Asia is proposed.

    14. Professional killer cell deficiencies and decreased survival in pulmonary arterial hypertension (pages 1271–1277)

      Adrienne L Edwards, Sarah P Gunningham, Geoffrey C Clare, Matthew W Hayman, Mark Smith, Christopher MA Frampton, Bridget A Robinson, Richard W Troughton and Lutz EL Beckert

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12152

      Deficiencies of cytotoxic CD8+ T-lymphocytes and natural killer cells in patients with idiopathic and connective tissue disease-associated pulmonary arterial hypertension are associated with an increased risk of death. For the first time, lymphocyte depletion has been shown to be an adverse prognostic marker in patients with pulmonary arterial hypertension.

  5. SCIENTIFIC LETTERS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. Chronic cough management: dealing with a sensation of irritation in the throat (pages 1278–1279)

      Haruhiko Ogawa, Masaki Fujimura, Noriyuki Ohkura and Koichi Makimura

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12166

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      Exacerbation phenotyping in chronic obstructive pulmonary disease (pages 1280–1281)

      Martin MacDonald, Tony Korman, Paul King, Kais Hamza and Philip Bardin

      Article first published online: 28 OCT 2013 | DOI: 10.1111/resp.12197

  6. FORTHCOMING MEETINGS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. You have free access to this content
      Forthcoming Meetings (page 1282)

      Article first published online: 28 OCT 2013 | DOI: 10.1111/j.1440-1843.2013.02240.x

  7. JOURNAL STATISTICS

    1. Top of page
    2. EDITORIALS
    3. INVITED REVIEW SERIES
    4. REVIEW
    5. ORIGINAL ARTICLES
    6. SCIENTIFIC LETTERS
    7. FORTHCOMING MEETINGS
    8. JOURNAL STATISTICS
    1. You have free access to this content
      Journal Statistics (page 1282)

      Article first published online: 28 OCT 2013 | DOI: 10.1111/j.1440-1843.2013.02240_2.x

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