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Evaluating the Potential for a Helicobacter pylori Drinking Water Guideline

Authors

  • Michael Ryan,

    Corresponding author
    1. Department of Civil Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA
    • Address correspondence to Michael Ryan, Department of Civil Architectural and Environmental Engineering, Drexel University, 3141 Chestnut Street, Curtis 251, Philadelphia, PA 19104, USA; tel: 215-571-4779; mor23@drexel.edu.

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  • Kerry Hamilton,

    1. Department of Civil Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA
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  • Michael Hamilton,

    1. Department of Civil Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA
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  • Charles N. Haas

    1. Department of Civil Architectural and Environmental Engineering, Drexel University, Philadelphia, PA, USA
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Abstract

Helicobacter pylori is a microaerophilic, gram-negative bacterium that is linked to adverse health effects including ulcers and gastrointestinal cancers. The goal of this analysis is to develop the necessary inputs for a quantitative microbial risk assessment (QMRA) needed to develop a potential guideline for drinking water at the point of ingestion (e.g., a maximum contaminant level, or MCL) that would be protective of human health to an acceptable level of risk while considering sources of uncertainty. Using infection and gastric cancer as two discrete endpoints, and calculating dose-response relationships from experimental data on humans and monkeys, we perform both a forward and reverse risk assessment to determine the risk from current reported surface water concentrations of H. pylori and an acceptable concentration of H. pylori at the point of ingestion. This approach represents a synthesis of available information on human exposure to H. pylori via drinking water. A lifetime risk of cancer model suggests that a MCL be set at <1 organism/L given a 5-log removal treatment because we cannot exclude the possibility that current levels of H. pylori in environmental source waters pose a potential public health risk. Research gaps include pathogen occurrence in source and finished water, treatment removal rates, and determination of H. pylori risks from other water sources such as groundwater and recreational water.

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