SEARCH

SEARCH BY CITATION

FilenameFormatSizeDescription
risa12194-sup-0001-FigureS1.docx24256K

Figure 1: Dose-response data of liver tumor incidence against the log10 aflatoxin B1 dose (ppb).

Figure 2: Uncertainty distributions for (log10) ED50 and BMDs (μg/kg bw/d) associated with various BMRs obtained by combining the bootstrap results from all seven accepted models.

Figure 3: Dose-response data of liver tumor incidence against the log10 NDMA dose (mg/kg bw/day).

Figure 4: Uncertainty distributions for (log10) ED50 and BMDs (mg/kg bw/d) associated with various BMRs obtained by combining the bootstrap results from all four accepted models.

Figure 5: Dose-response data of liver tumor incidence against the log10 methyleugenol dose (mg/kg bw/day).

Figure 6: Uncertainty distributions for (log10) ED50 and BMDs (mg/kg bw/d) associated with various BMRs obtained by combining the bootstrap results from all seven accepted models.

Figure 8: Contribution of various sources of uncertainty (Monte Carlo, consumption data, concentration data, processing factor, and BMD) to the overall uncertainty associated with the 1st percentile of the MOE distribution of (A) aflatoxin B1, (B) NDMA from fish and vegetables, (C) NDMA from other sources, and (D) methyleugenol. This analysis is limited to the quantified uncertainties in the applied risk assessment approach, i.e., other uncertainties may exist that are currently not included.

Figure 9: The 1st percentile of the IMoE (=ICED/IEXP) distribution (on log10 scale), given as 90% confidence intervals. Left axis: individual cancer risk; right axis: IPRA approach B or C.

Figure 10: The percentage of the population with IMoE < 1 (i.e., IEXP > ICED).

Figure 11: Aflatoxin B1: Contribution of various sources of uncertainty (intra- and interspecies extrapolation, BMD, processing factor, concentration data, consumption data, Monte Carlo) to the overall uncertainty associated with the 1st percentile of the IMoE distribution for several IPRA approaches.

Figure 12: NDMA from fish and vegetables: Contribution of various sources of uncertainty (intra- and interspecies extrapolation, BMD, processing factor, concentration data, consumption data, Monte Carlo) to the overall uncertainty associated with the 1st percentile of the IMoE distribution for several IPRA approaches.

Figure 13: NDMA from other sources: Contribution of various sources of uncertainty (intra- and interspecies extrapolation, BMD, processing factor, concentration data, consumption data, Monte Carlo) to the overall uncertainty associated with the 1st percentile of the IMoE distribution for several IPRA approaches.

Figure 14: Methyleugenol: Contribution of various sources of uncertainty (intra- and interspecies extrapolation, BMD, processing factor, concentration data, consumption data, Monte Carlo) to the overall uncertainty associated with the 1st percentile of the IMoE distribution for several IPRA approaches.

Table 1: Summary data of the intake.

Table 2: Incidences of liver tumors in male rats after prolonged exposure to various doses of aflatoxin B1 (Wogan et al., 1974).

Table 3: Summary of the BMD and ED50 distributions of aflatoxin B1 obtained with all seven accepted models, combined.

Table 4: Incidences of liver tumors in rats after prolonged exposure to various doses of NDMA (Peto et al., [34], [35]).

Table 5: Summary of the BMD and ED50 distributions of NDMA obtained with all four accepted models combined.

Table 6: Incidences of liver tumors in rats after two-year exposure to various doses of methyleugenol (NTP 2000)

Table 7: Summary of the BMD and ED50 distributions of methyleugenol obtained with all seven accepted models combined.

Table 8: EF distributions (all lognormally distributed).

Table 9: Results for approach A.

Table 10: Confidence intervals for the 1st percentile of the IMoE distribution

Table 11: Confidence intervals for fraction of the population with IMoE < 1

Table 12: Summary of estimated risks.

Appendix A: Products present in the DNFCS expected to contain basil.

Appendix B: Fitted models to the tumor incidence data of aflatoxin B1.

Appendix C: Fitted models to the tumor incidence data of NDMA.

Appendix D: Fitted models to the tumor incidence data of methyleugenol.

Please note: Wiley Blackwell is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.