Recent studies in system resilience have proposed metrics to understand the ability of systems to recover from a disruptive event, often offering a qualitative treatment of resilience. This work provides a quantitative treatment of resilience and focuses specifically on measuring resilience in infrastructure networks. Inherent cost metrics are introduced: loss of service cost and total network restoration cost. Further, “costs” of network resilience are often shared across multiple infrastructures and industries that rely upon those networks, particularly when such networks become inoperable in the face of disruptive events. As such, this work integrates the quantitative resilience approach with a model describing the regional, multi-industry impacts of a disruptive event to measure the interdependent impacts of network resilience. The approaches discussed in this article are deployed in a case study of an inland waterway transportation network, the Mississippi River Navigation System.