Case History Report
Dentin decalcification during lithium treatment: case report
Article first published online: 22 NOV 2012
©2012 Special Care Dentistry Association and Wiley Periodicals, Inc.
Special Care in Dentistry
Volume 33, Issue 2, pages 91–95, March/April 2013
How to Cite
Eduardo, C. d. P., Simões, A., de Freitas, P. M., Arana-Chavez, V. E., Nicolau, J. and Gentil, V. (2013), Dentin decalcification during lithium treatment: case report. Special Care in Dentistry, 33: 91–95. doi: 10.1111/scd.12000
- Issue published online: 1 MAR 2013
- Article first published online: 22 NOV 2012
- State of São Paulo Research Foundation. Grant Number: # 98/14270-8
- National Council for Scientific and Technological Development. Grant Numbers: # 552210/2005-0, 303925/2007-8
- lithium treatment;
- bipolar disorder
Severe dental decay and changes in tooth structure have been reported in association with the use of lithium in Psychiatry, but lithium effects on tooth inorganic composition remain unknown. A 30-year-old woman with bipolar disorder, treated with lithium carbonate presented severe dental decay. Dentin samples from lithium and healthy volunteers were collected and submitted to ionic and ultrastructural analysis. Samples from the lithium patient exhibited irregular peritubular walls and the mineral crystals were irregularly arranged in the intertubular dentin. In addition, a decrease in Mg/P/Ca and an increase of Zn concentrations were detected. These data suggest that the severe dental decay and changes in the tooth structure observed for the lithium-treated patient are related to dentin mineral loss and that this pathological condition is different from caries lesions.