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From Basic Biology to Randomized Clinical Trial: The Beta Radiation for ArterioVenous Graft Outflow Stenosis (BRAVO II)

Authors


Address correspondence to: Prabir Roy-Chaudhury, MD, PhD, Division of Nephrology, University of Cincinnati, MSB 6009, 231 Albert Sabin Way, Cincinnati, OH 45267-0585, Tel.: (513) 558 4006, Fax: (513) 558 4309, or e-mail: prabir.roychaudhury@uc.edu.

Abstract

The BRAVO-II study was a randomized controlled study of endovascular radiation therapy as compared to sham radiation therapy, following angioplasty of a thrombosed PRFE graft. The results did not show a benefit of endovascular radiation therapy, albeit in the context of an early termination of the study at less than 50% enrollment due to business reasons. Emphasis is laid on the fact that there may still be a role for radiation therapy in specific clinical settings associated with dialysis vascular access dysfunction.

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