Because of its advantages, the transradial approach for cardiovascular interventions has gained significant popularity. However, this approach can be associated with radial artery thrombosis and occlusion. The complication generates a major concern for its potential impact on the future creation of an arteriovenous hemodialysis access. The issue gains more importance as a significant number of patients with cardiovascular disease suffer from underlying chronic kidney disease (CKD) and might need an arteriovenous access for hemodialysis therapy. In this context, the preservation of the arterial system is of equal importance to the frequently highlighted venous conservation for the successful creation of an arteriovenous access. It is for this reason that the Fistula First Breakthrough Initiative recommends avoiding the use of the radial artery for performing percutaneous interventions in patients with advanced CKD. Furthermore, there is scarce clinical data and publication regarding the impact of transradial approach on hemodialysis access. Is it possible to utilize the potential benefits and minimize the potential risks of transradial approach in chronic kidney disease patients? On the basis of current knowledge, this review discusses related issues of transradial approach to raise awareness and understanding, which are essential to proper caring of CKD patients undergoing cardiovascular interventions.