Iron and Infection in Hemodialysis Patients
Article first published online: 12 DEC 2013
© 2013 Wiley Periodicals, Inc.
Seminars in Dialysis
Volume 27, Issue 1, pages 26–36, January–February 2014
How to Cite
Ishida, J. H. and Johansen, K. L. (2014), Iron and Infection in Hemodialysis Patients. Seminars in Dialysis, 27: 26–36. doi: 10.1111/sdi.12168
- Issue published online: 9 JAN 2014
- Article first published online: 12 DEC 2013
- American Society of Nephrology
- NIDDK. Grant Number: K24DK085153
Intravenous iron is an important component of the treatment of anemia of end-stage renal disease (ESRD), but it is biologically plausible that iron could increase the risk of infection through impairment of neutrophil and T-cell function and promotion of microbial growth. Any such increase in risk would be particularly important because infection is a significant cause of mortality and morbidity in dialysis patients. The overall evidence favors an association between iron and infection in hemodialysis patients, but the optimal iron management strategy to minimize infection risk has yet to be identified. There is a need for further research on this topic, particularly in light of increased utilization of intravenous iron following implementation of the bundled ESRD reimbursement system.