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sji12041-sup-0001-S1.epsimage/eps782KFigure S1. PGE2 and cytokine response to IL-1blow/HMGB1 complexes in three representative patients to depict inter-patient variability. SFs were cultured in the presence of IL-1b and HMGB1 separately or in complex. PGE2 production and cytokine release were measured in supernatants after 24 h of stimulation. Mediator production obtained when using rHMGB1 (A) PGE2 B) IL-6 C) IL-8 D) MCP-1 E) RANTES. PGE2 was measures by EIA and cytokines by CBA. Data is expressed in pg/ml.

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