Polymorphism in the Interleukin-7 Receptor-alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor
Version of Record online: 21 JUL 2013
© 2013 John Wiley & Sons Ltd.
Scandinavian Journal of Immunology
Volume 78, Issue 2, pages 214–220, August 2013
How to Cite
Shamim, Z., Spellman, S., Haagenson, M., Wang, T., Lee, S. J., Ryder, L. P. and Müller, K. (2013), Polymorphism in the Interleukin-7 Receptor-alpha and Outcome after Allogeneic Hematopoietic Cell Transplantation with Matched Unrelated Donor. Scandinavian Journal of Immunology, 78: 214–220. doi: 10.1111/sji.12077
- Issue online: 21 JUL 2013
- Version of Record online: 21 JUL 2013
- Accepted manuscript online: 21 MAY 2013 06:29AM EST
- Manuscript Accepted: 30 APR 2013
- Manuscript Received: 29 JAN 2013
- Danish Cancer Society (junior scholarship DP06075)
- The Danish Child Cancer Foundation
- The Lundbeck Foundation and U.S. Office of Naval Research
- National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID). Grant Number: U24-CA76518
- NHLBI and NCI. Grant Number: 5U01HL069294
- Health Resources and Services Administration (HRSA/DHHS). Grant Number: HHSH234200637015C
- Office of Naval Research. Grant Numbers: N00014-06-1-0704, N00014-08-1-0058
- American Society for Blood and Marrow Transplantation
- Amgen, Inc.
- Anonymous donation to the Medical College of Wisconsin
- Astellas Pharma US, Inc.
- Baxter International, Inc.
- Bayer HealthCare Pharmaceuticals
- Be the Match Foundation
- Biogen IDEC
- BioMarin Pharmaceutical, Inc.
- Biovitrum AB
- BloodCenter of Wisconsin
- Blue Cross and Blue Shield Association
- Bone Marrow Foundation
- Canadian Blood and Marrow Transplant Group
- Celgene Corporation
- CellGenix, GmbH
- Centers for Disease Control and Prevention
- Children's Leukemia Research Association
- ClinImmune Labs
- CTI Clinical Trial and Consulting Services
- Cubist Pharmaceuticals
- Cylex Inc.
- DOR BioPharma, Inc.
- Dynal Biotech, an Invitrogen Company
- Eisai, Inc.
- Enzon Pharmaceuticals, Inc.
- European Group for Blood and Marrow Transplantation
- Gamida Cell, Ltd.
- GE Healthcare
- Genentech, Inc.
- Genzyme Corporation
- Histogenetics, Inc.
- HKS Medical Information Systems
- Hospira, Inc.
- Infectious Diseases Society of America
- Kiadis Pharma
- Kirin Brewery Co., Ltd.
- The Leukemia & Lymphoma Society; Merck & Company
- The Medical College of Wisconsin
- MGI Pharma, Inc.
- Michigan Community Blood Centers
- Millennium Pharmaceuticals, Inc.
- Miller Pharmacal Group
- Milliman USA, Inc.
- Miltenyi Biotec, Inc.
- National Marrow Donor Program
- Nature Publishing Group
- New York Blood Center
- Novartis Oncology
- Oncology Nursing Society
- Osiris Therapeutics, Inc.
- Otsuka America Pharmaceutical, Inc.
- Pall Life Sciences
- Pfizer Inc
- Saladax Biomedical, Inc.
- Schering Corporation
- Society for Healthcare Epidemiology of America
- Soligenix, Inc.
- StemCyte, Inc.
- StemSoft Software, Inc.
- Sysmex America, Inc.
- THERAKOS, Inc.
- Thermogenesis Corporation
- Vidacare Corporation
- Vion Pharmaceuticals, Inc.
- ViraCor Laboratories
- ViroPharma, Inc.
- Wellpoint, Inc.
Interleukin-7 (IL-7) is essential for T cell development in the thymus and maintenance of peripheral T cells. The α-chain of the IL-7R is polymorphic with the existence of SNPs that give rise to non-synonymous amino acid substitutions. We previously found an association between donor genotypes and increased treatment-related mortality (TRM) (rs1494555G) and acute graft versus host disease (aGvHD) (rs1494555G and rs1494558T) after hematopoietic cell transplantation (HCT). Some studies have confirmed an association between rs6897932C and multiple sclerosis. In this study, we evaluated the prognostic significance of IL-7Rα SNP genotypes in 590-recipient/donor pairs that received HLA-matched unrelated donor HCT for haematological malignancies. Consistent with the primary studies, the rs1494555GG and rs1494558TT genotypes of the donor were associated with aGvHD and chronic GvHD in the univariate analysis. The Tallele of rs6897932 was suggestive of an association with increased frequency of relapse by univariate analysis (P = 0.017) and multivariate analysis (P = 0.015). In conclusion, this study provides further evidence of a role of the IL-7 pathway and IL-7Rα SNPs in HCT.