Relationship between aerobic endurance training and dynamic cerebral blood flow regulation in humans

Authors

  • D. Ichikawa,

    1. Department of Biomedical Engineering, Toyo University, Kawagoe-Shi, Saitama, Japan
    2. Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo-shi, Yamanashi, Japan
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  • T. Miyazawa,

    1. Research Institute of Industrial Technology, Toyo University, Kawagoe-Shi, Saitama, Japan
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  • M. Horiuchi,

    1. Research Institute of Industrial Technology, Toyo University, Kawagoe-Shi, Saitama, Japan
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  • T. Kitama,

    1. Center for Life Science Research, University of Yamanashi, Chuo-shi, Yamanashi, Japan
    2. Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, Chuo-shi, Yamanashi, Japan
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  • J. P. Fisher,

    1. School of Sport and Exercise Sciences, University of Birmingham, Birmingham, UK
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  • S. Ogoh

    Corresponding author
    1. Research Institute of Industrial Technology, Toyo University, Kawagoe-Shi, Saitama, Japan
    • Department of Biomedical Engineering, Toyo University, Kawagoe-Shi, Saitama, Japan
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Corresponding author: Shigehiko Ogoh, PhD, Department of Biomedical Engineering, Toyo University, 2100 Kujirai, Kawagoe-shi, Saitama 350-8585, Japan. Tel: +81 049 239 1327, Fax: +81 049 231 5026, E-mail: ogoh@toyo.jp

Abstract

The incidence of orthostatic intolerance is elevated in endurance-trained individuals. We sought to test the hypothesis that aerobic endurance training is associated with an attenuated control of the cerebral vasculature. Endurance trained (ET, n = 13) and age-matched untrained (UT, n = 11) individuals (peak O2 consumption, mean ± SEM; 63 ± 1 vs 42 ± 1 mL/min/kg, P < 0.05) were examined while supine and seated upright. Dynamic cerebral autoregulation (CA) was assessed by calculation of the rate of regulation (RoR) from the arterial blood pressure (ABP) and middle cerebral artery (MCA) mean blood velocity (Vmean) responses to a bilateral thigh cuff release, which evoked a transient hypotension. Cerebral oxygenation (oxyhemoglobin; HbO2) was determined with near-infrared spectroscopy. When seated upright, cuff release evoked a greater decrease in ABP (P < 0.001), MCA Vmean (P = 0.096) and HbO2 (P < 0.001) in ET compared with UT. However, RoR was similar in ET and UT individuals while seated upright (to 0.193 ± 0.039 vs 0.129 ± 0.029/s, P > 0.05), and there was no significant difference in the relative change in RoR from the supine to upright positions (ΔRoR: −65 ± 7 and −69 ± 7%, for ET and UT, respectively). These findings suggest that aerobic endurance training is not associated with an attenuation in dynamic CA.

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