The effect of relaxin on the musculoskeletal system


  • The copyright line for this article was changed on 10 July 2014 after original online publication.
  • Jason L Dragoo and Naguib Salleh have equal contribution in preparation of this manuscript.


Relaxin is a hormone structurally related to insulin and insulin-like growth factor, which exerts its regulatory effect on the musculoskeletal and other systems through binding to its receptor in various tissues, mediated by different signaling pathways. Relaxin alters the properties of cartilage and tendon by activating collagenase. This hormone is also involved in bone remodeling and healing of injured ligaments and skeletal muscle. In this review, we have summarized the literature on the effect of relaxin in musculoskeletal system to provide a broad perspective for future studies in this field.