Given the mounting empirical evidence to support both the cultural and biological shaping of emotional processes, there is a clear need to integrate these determinants of emotional processes. Much in the same vein as these efforts, in our research on gene-culture interactions, we have examined how cultural and biological factors jointly influence emotion regulation. The present paper specifically aims to present research considering both cultural and genetic factors as two interacting influences that shape emotion regulation. A series of studies conducted to test the gene-culture interaction involving OXTR rs53576 consistently show that individuals with the variant that is associated with socio-emotional sensitivity tend to utilize culturally normative forms of emotion regulation more than those without it. These findings underscore the importance of considering the interplay between socio-cultural and genetic factors that shape social behaviors.