Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study
Version of Record online: 19 JAN 2013
© 2013 John Wiley & Sons A/S. Published by Blackwell Publishing Ltd
Skin Research and Technology
Volume 19, Issue 2, pages 125–130, May 2013
How to Cite
Zheng, Y., Wan, M., Chen, H., Ye, C., Zhao, Y., Yi, J., Xia, Y. and Lai, W. (2013), Clinical evidence on the efficacy and safety of an antioxidant optimized 1.5% salicylic acid (SA) cream in the treatment of facial acne: an open, baseline-controlled clinical study. Skin Research and Technology, 19: 125–130. doi: 10.1111/srt.12022
- Issue online: 12 APR 2013
- Version of Record online: 19 JAN 2013
- Manuscript Accepted: 10 NOV 2012
- salicylic acid;
- penetration enhancers
Acne pathogenesis is multifactorial and includes inflammation. Combining active ingredients targeting multiple components of acne pathogenesis may yield optimal outcomes. This study investigates the safety and efficacy of an antioxidant optimized topical salicylic acid (SA) 1.5% cream containing natural skin penetration enhancers in combination with antioxidant activity for treatment of facial acne.
A total of 20 patients with facial acne, aged 19–32 years (2 males, 18 females; mean age 26.1 ± 3.2), were enrolled. Patients were treated with topical 1.5% SA cream and instructed to apply the cream as a thin film over the affected area twice daily (in the morning and evening) for 4 weeks. Inflammatory severity, numbers of papules and pustules were evaluated by investigators at day 0 and weekly, and patients ranked their improvement.
In all, 95% of patients improved: 20% had complete clearing, 30% had significantly improved, 15% had moderate improvement, 30% had mild improved, and there was no response in 5% of the patients by 4 weeks of treatment. No side effects were observed.
This study demonstrates the efficacy and safety of this optimized topical 1.5% SA cream containing natural skin penetration enhancers in combination with antioxidant activity when applied twice daily for the reduction of facial acne; in particular, it is most effective for mild-to-moderate acne.