Evaluation of optical coherence tomography as a non-invasive diagnostic tool in cutaneous wound healing

Authors

  • Monika Kuck,

    Corresponding author
    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
    • Address:

      Monika Kuck

      Department of Dermatology, Venerology and Allergology

      Center of Experimental and Applied Cutaneous Physiology (CCP)

      Charité – Universitätsmedizin Berlin

      Charitéplatz 1

      Berlin 10117

      Germany

      Tel: + 49 30 450 518 106

      Fax: + 49 30 450 518 918

      e-mail: monika.kuck@charite.de

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  • Helene Strese,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Seyed Arash Alawi,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Martina C. Meinke,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Joachim W. Fluhr,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Guido J. Burbach,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Martin Krah,

    1. Development of Optoelectronic Devices and SD-OCT, Thorlabs GmbH, Dachau, Germany
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  • Wolfram Sterry,

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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  • Jürgen Lademann

    1. Department of Dermatology, Venerology and Allergology, Center of Experimental and Applied Cutaneous Physiology (CCP), Charité – Universitätsmedizin Berlin, Berlin, Germany
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Abstract

Background

The monitoring of wound-healing processes is indispensable for the therapeutic effectiveness and improved care of chronic wounds. Histological sections provide the best morphological assessment of wound recovery, but cause further tissue destruction and increase the risk of infection. Therefore, it is reasonable to apply a diagnostic tool that allows a non-invasive and reliable observation of morphological changes in wound healing.

Methods

Optical coherence tomography (OCT) is an imaging technique for in vivo evaluation of skin diseases with a resolution close to histopathology. The aim of this study was to investigate whether OCT is suited to display the phases of wound healing. For this purpose, six patients with chronic wounds were objectively characterized by OCT during a period of 2 weeks.

Results

Comparable results between histological findings and OCT were achieved. OCT allowed the detection of partial loss of the epidermis, vasoconstriction, vasodilatation and epithelialization.

Conclusion

Consequently, OCT could be a potential non-invasive diagnostic tool for the characterization and monitoring of cutaneous wound-healing processes over time.

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