Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial
Version of Record online: 5 SEP 2013
© 2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Skin Research and Technology
Volume 20, Issue 2, pages 208–212, May 2014
How to Cite
Lee, D. H., Oh, I. Y., Koo, K. T., Suk, J. M., Jung, S. W., Park, J. O., Kim, B. J. and Choi, Y. M. (2014), Reduction in facial hyperpigmentation after treatment with a combination of topical niacinamide and tranexamic acid: a randomized, double-blind, vehicle-controlled trial. Skin Research and Technology, 20: 208–212. doi: 10.1111/srt.12107
- Issue online: 17 APR 2014
- Version of Record online: 5 SEP 2013
- Manuscript Accepted: 18 JUL 2013
- the Ministry of Knowledge Economy (MKE)
- Korea Institute for Advancement of Technology (KIAT)
- facial hyperpigmentation;
- tranexamic acid
Facial hyperpigmentation occurs in multiple conditions. In addition, many Asian women desire a lighter skin color. Thus, there is a need for the development of skin lightening agents, and niacinamide and tranexamic acid (TXA) are promising candidates.
To assess the effectiveness of a combination of niacinamide and TXA as a topical moisturizing formulation for treatment of irregular facial pigmentation.
Materials and Methods
A total of 42 Korean women (age range: 30–60 years) who were not pregnant, nursing, or undergoing any concurrent therapy were enrolled in this study for 8 weeks. Subjects used a twice-daily regimen of either a moisturizing cream containing 2% niacinamide + 2% TXA (test formulation; n = 21) or cream vehicles (vehicle control; n = 21) in addition to an assigned sunscreen each morning. Pigmentation was measured objectively using a mexameter and chromameter, in addition to physicians' assessment using clinical photographs.
The niacinamide + TXA formulation regimen was significantly (P < 0.05) more effective than the vehicle control formulation regimen in reducing the appearance of pigmentation.
A formulation containing the combination of niacinamide + TXA reduced the appearance of irregular pigmentation, providing an effect beyond that achieved with sunscreen.