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Implication of HLA-G 3′ untranslated region polymorphisms in human papillomavirus infection

Authors

  • D. Bortolotti,

    1. Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy
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  • V. Gentili,

    1. Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy
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  • A. Rotola,

    1. Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy
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  • D. Di Luca,

    1. Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy
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  • R. Rizzo

    Corresponding author
    1. Department of Medical Sciences, Section of Microbiology and Medical Genetics, University of Ferrara, Ferrara, Italy
    • Correspondence

      Roberta Rizzo

      Department of Medical Sciences

      Section of Microbiology

      University of Ferrara

      Via Luigi Borsari 46

      Ferrara 44122

      Italy

      Tel: +39 0532 455 382

      Fax: +39 0532 974 470

      e-mail: rbr@unife.it

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Abstract

Human papillomavirus (HPV) infection is involved in cervical lesion development. It interferes with host immune response and modifies the expression of human leukocyte antigen-G (HLA-G), a nonclassical HLA-I antigen with immune-inhibitory functions. We analyzed the frequencies of two HLA-G 3′ untranslated region polymorphisms (14 bp ins/del, +3142C>G), involved in HLA-G modulation, in 33 condyloma acuminatum, 14 low grade squamous intraepithelial lesion and 100 invasive cervical cancer (ICC) HPV infected patients. We showed the involvement of HLA-G polymorphisms in HPV infection and lesion development, and suggested that 14 bp del allele promotes high-risk HPV infection, with del/C haplotype associated with ICC development. On the basis of these evidences, HLA-G polymorphisms could represent a risk factor in HPV positive subjects.

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