Columnar Cell Change With Atypia (Flat Epithelial Atypia) on Breast Core Biopsy—Outcomes Following Open Excision
Article first published online: 18 OCT 2012
© 2012 Wiley Periodicals, Inc.
The Breast Journal
Volume 18, Issue 6, pages 578–581, November/December 2012
How to Cite
Biggar, M. A., Kerr, K. M., Erzetich, L. M. and Bennett, I. C. (2012), Columnar Cell Change With Atypia (Flat Epithelial Atypia) on Breast Core Biopsy—Outcomes Following Open Excision. The Breast Journal, 18: 578–581. doi: 10.1111/tbj.12039
- Issue published online: 5 NOV 2012
- Article first published online: 18 OCT 2012
- breast cancer;
- columnar cell change;
- ductal intraepithelial neoplasia;
- flat epithelial atypia;
- precancerous lesions
Columnar cell change with atypia (CCCA) is a relatively recently recognized pathologic breast entity considered to be a risk factor for subsequent development of breast carcinoma. The aim of this study was to investigate the significance of finding CCCA on breast core biopsy, by establishing the frequency of other breast pathology on subsequently performed surgical excision specimens. All cases with CCCA as the most advanced lesion on core biopsy were reviewed. After excision, another advanced proliferative lesion was identified in 17 (33%) patients, including three patients (6%) with in situ or invasive carcinoma. An additional five patients (10%) were concurrently diagnosed with primary breast carcinoma at other sites. These findings indicate that when CCCA is found on core biopsy, open surgical biopsy of the relevant area should be performed and that workup of both breasts should be undertaken to exclude coexistent breast carcinoma at alternative sites.