We present a geomorphologic analysis of an east-west transect located east of the southern Andes of Argentina (~37°S). We observe a succession of zones that underwent erosion and deposition during the Pleistocene. If the proximal Andean foothills are incised, a proximal depozone receives sediments feeding the megafan of the Rio Colorado on the Chadileuvú plain. More distally, the abandoned palaeo-valleys and bending of the valley floors reflect a localized uplift. Further to the east, another depozone corresponds to the Pampa Deprimida lowland. This pattern is consistent with the presence of a classical flexural geometry of the lithosphere. The distal uplift of the foreland corresponds in terms of location, length (150 km) and amplitude (240 m) to the Andean forebulge modelled by a geophysical approach. In this study, we identify the morphological imprint of this bulge and show its effect on the fluvial activity.