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Aspergillosis after liver transplantation in the context of common variable immunodeficiency: case report

Authors

  • Y. Chen,

    1. Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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  • A. Cameron

    Corresponding author
    1. Department of Surgery, Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
    • Johns Hopkins School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA
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Correspondence to:

Andrew M. Cameron, MD, PhD, Department of Surgery, The John Hopkins University, 720 Rutland Ave, Ross 765, Baltimore, MD 21205, USA

Tel: 410 614 5700

Fax: 410 510 1526

E-mail: acamero5@jhmi.edu

Abstract

Common variable immunodeficiency (CVID) is the most common primary immune defect, resulting in hypogammaglobulinemia as well as deficits in cell-mediated immunity. Although it mainly manifests in immunodeficiency and related infection, CVID can also be associated with autoimmune phenomena such as immune thrombocytopenic purpura, hemolytic anemia, rheumatoid arthritis, lupus, primary biliary cirrhosis, and autoimmune hepatitis (AIH). AIH is a less common but serious complication of CVID, which can result in early cirrhosis, ascites, and even hepatocellular carcinoma. Here, we discuss a recent case of transplantation for cirrhosis secondary to AIH in the context of CVID. Although the patient's surgery occurred without complication, he rapidly developed fulminant alveolar hemorrhage and seizures, and died secondary to disseminated neuroaspergillosis.

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