The use of chromosomal microarray in prenatal diagnosis
Correspondence: Sarah Hillman. Email: email@example.com
- The results of prenatal fetal chromosomal analysis may inform long term prognosis.
- Recent advances in chromosome microarray (CMA) are enabling genome-wide evaluation of submicroscopic chromosomal changes.
- Such technological advances promise increased sensitivity and specificity. They also potentially pose challenges of interpretation and clinical management.
- To systematically review the current literature and explain the benefit and pitfalls of CMAs and their relevance to the practising obstetrician in the NHS.
- Comment on the future of CMA and its cost effectiveness.
- Difficulties of informed consent with genome-wide prenatal testing.
- Difficulties surround results of unknown significance.