The use of chromosomal microarray in prenatal diagnosis
Article first published online: 19 APR 2013
© 2013 Royal College of Obstetricians and Gynaecologists
The Obstetrician & Gynaecologist
Volume 15, Issue 2, pages 80–84, April 2013
How to Cite
Please cite this paper as: The use of chromosomal microarray in prenatal diagnosis. The Obstetrician & Gynaecologist 2013;15:80–4., , , .
- Issue published online: 19 APR 2013
- Article first published online: 19 APR 2013
- Manuscript Accepted: 14 NOV 2012
- chromosomal microarray;
- prenatal diagnosis
- The results of prenatal fetal chromosomal analysis may inform long term prognosis.
- Recent advances in chromosome microarray (CMA) are enabling genome-wide evaluation of submicroscopic chromosomal changes.
- Such technological advances promise increased sensitivity and specificity. They also potentially pose challenges of interpretation and clinical management.
- To systematically review the current literature and explain the benefit and pitfalls of CMAs and their relevance to the practising obstetrician in the NHS.
- Comment on the future of CMA and its cost effectiveness.
- Difficulties of informed consent with genome-wide prenatal testing.
- Difficulties surround results of unknown significance.