Preventing recurrent miscarriage of unknown aetiology
Article first published online: 19 APR 2013
© 2013 Royal College of Obstetricians and Gynaecologists
The Obstetrician & Gynaecologist
Volume 15, Issue 2, pages 99–105, April 2013
How to Cite
Preventing recurrent miscarriage of unknown aetiology. The Obstetrician & Gynaecologist 2013;15:99–105., , .
- Issue published online: 19 APR 2013
- Article first published online: 19 APR 2013
- Manuscript Accepted: 25 NOV 2012
- human chorionic gonadotrophin;
- recurrent miscarriage
- One to three per cent of couples are affected by recurrent miscarriage (defined as more than three consecutive pregnancy losses).
- Current interventions are centred on known causes of aetiology.
- Recent research on miscarriage of unknown cause has investigated the requirements for successful embryo implantation.
- Treatment of immunological risk factors with immunotherapy does not have a strong evidence base.
- The overall evidence supporting the use of human chorionic gonadotrophin supplementation during pregnancy is inconclusive.
- The efficacy of progesterone as an intervention remains empirical, with further trials under way.
- To understand the aetiology of recurrent miscarriage and patient risk factors.
- To understand the theoretical pathophysiology underlying miscarriage of unknown aetiology.
- To be aware of the potential agents of intervention for recurrent miscarriage and their efficacy.
- Treating patients with recurrent miscarriage can be emotive; should women be treated with interventions that have limited evidence-based clinical efficacy?
- How do we manage patients with the psychological impact of recurrent miscarriage?