• fertility;
  • in vitro fertilisation;
  • in vitro maturation;
  • polycystic ovary syndrome

Key content

  • In vitro maturation is an alternative to in vitro fertilisation for young women with polycystic ovary syndrome and young ovulatory women.
  • In vitro maturation accomplishes the maturation of immature oocytes in the laboratory, thus minimising or avoiding gonadotrophin stimulation and the associated cost, side-effects and risks.
  • Pregnancy rates are lower with in vitro maturation than with in vitro fertilisation.

Learning objectives

  • To define appropriate candidates for in vitro maturation.
  • To review variations in protocols and laboratory aspects of in vitro maturation and the rationale for these variations.
  • To highlight outcome data from in vitro maturation cycles.

Ethical issues

  • Infertile couples must consider both the risks and benefits of in vitro maturation and make an informed decision regarding their treatment options.
  • Further long-term outcome data regarding the health of children born through in vitro maturation is necessary.