Re: The relationship between infertility treatment and cancer including gynaecological cancers


Dear Sir

Louis et al[1] are to be commended for the multiple studies they analysed for their article on the evidence of infertility treatment and cancer.

We wondered if the authors had considered presenting the data graphically in a forest (meta-analysis) plot. Furthermore, as fertility treatments such as clomiphene citrate have been used for over 50 years, and in vitro fertilisation for over 30 years, we were surprised by the suggestion in the penultimate paragraph that most of the treated patients have not reached the age of peak incidence for gynaecological cancers, given that the average age of infertility is 30 to 35 years and the peak incidence of ovarian cancer is 60 years, achieving a plateau after the age of 65.