Retinoids and pregnancy: an update
- The use and pharmacokinetics of retinoids.
- The main known teratogenic effects of retinoids are face, skull, cardiovascular, nervous system and thymic abnormalities.
- The pregnancy prevention programme must be adhered to when initiating retinoid treatment.
- Effective contraception should be continued for at least one month after cessation of retinoid treatment.
- Management options of pregnant women with recent retinoid use or exposure in early pregnancy; including involvement of the specialist multidisciplinary team.
- To understand the risk and in particular teratogenesis associated with exposure to retinoids peri-conception.
- To raise awareness of the pregnancy prevention programme.
- To highlight the management options for women who become pregnant with recent retinoid use or exposure in early pregnancy.
- Termination of pregnancy with peri-conceptual exposure to retinoids.
- Should isotretinoin be used so widely in the childbearing population when we are aware of its teratogenicity?