SUMOylation represses SnRK1 signaling in Arabidopsis (pages 120–133)
Pierre Crozet, Leonor Margalha, Rafal Butowt, Noémia Fernandes, Carlos A. Elias, Beatriz Orosa, Konstantin Tomanov, Markus Teige, Andreas Bachmair, Ari Sadanandom and Elena Baena-González
Version of Record online: 30 DEC 2015 | DOI: 10.1111/tpj.13096
The SnRK1 protein kinase is crucial for tolerance to environmental stress and for a wide range of plant growth and developmental processes, but how its activity is regulated is unknown. Here, we demonstrate that SnRK1 activity causes its own SUMOylation and subsequent ubiquitination and proteasomal degradation, thus establishing a negative feedback loop that attenuates SnRK1 signaling and prevents detrimental sustained activation of stress responses.