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Fig. S1. The format is similar to Fig. 1 except now mean (±SE) changes in CI (panel A) and heart rate (panel B) are shown.

Fig. S2. The format is similar to Fig. 4 except instead during infusion (oxyHb, Panel A, and metHb, Panel B), the data post-infusion are shown (1-3 hr).

Fig. S3. The format is similar to Fig. 6 except now instead of oxyHb formed in vivo by reducing infused metHb, the metHb formed in vivo by oxidizing infused oxyHb is plotted from 0-3 hours (Panels A-E).

Fig. S4. The format is similar to Fig. 1 except now mean (±SE) changes in complete blood counts (panels A-D), electrolytes (panels E-H) and arterial blood gases (panels I-K) are shown. There were no significant differences throughout comparing treatment groups in all the panels (all, p = ns).

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