This study was conducted using intramural NIH funds and NIH grants HL058091 (DK-S) and HL098032 (MTG and DKS). MTG also receives research support from NIH grants RO1HL096973, and P01HL103455, the Institute for Transfusion Medicine and the Hemophilia Center of Western Pennsylvania. The work by the authors was done as part of US government-funded research; however, the opinions expressed are not necessarily those of the National Institutes of Health.
In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines
Article first published online: 14 MAR 2013
© 2013 American Association of Blood Banks
Volume 53, Issue 12, pages 3149–3163, December 2013
How to Cite
Wang, D., Piknova, B., Solomon, S. B., Cortes-Puch, I., Kern, S. J., Sun, J., Kanias, T., Gladwin, M. T., Helms, C., Kim-Shapiro, D. B., Schechter, A. N. and Natanson, C. (2013), In vivo reduction of cell-free methemoglobin to oxyhemoglobin results in vasoconstriction in canines. Transfusion, 53: 3149–3163. doi: 10.1111/trf.12162
- Issue published online: 9 DEC 2013
- Article first published online: 14 MAR 2013
- Manuscript Accepted: 25 JAN 2013
- Manuscript Revised: 24 JAN 2013
- Manuscript Received: 26 NOV 2012
- NIH. Grant Numbers: HL058091 (DK-S), HL098032 (MTG and DKS), RO1HL096973, P01HL103455
- Institute for Transfusion Medicine
- Hemophilia Center of Western Pennsylvania
Fig. S1. The format is similar to Fig. 1 except now mean (±SE) changes in CI (panel A) and heart rate (panel B) are shown.
Fig. S2. The format is similar to Fig. 4 except instead during infusion (oxyHb, Panel A, and metHb, Panel B), the data post-infusion are shown (1-3 hr).
Fig. S3. The format is similar to Fig. 6 except now instead of oxyHb formed in vivo by reducing infused metHb, the metHb formed in vivo by oxidizing infused oxyHb is plotted from 0-3 hours (Panels A-E).
Fig. S4. The format is similar to Fig. 1 except now mean (±SE) changes in complete blood counts (panels A-D), electrolytes (panels E-H) and arterial blood gases (panels I-K) are shown. There were no significant differences throughout comparing treatment groups in all the panels (all, p = ns).
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