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External validation and updating of a Dutch prediction model for low hemoglobin deferral in Irish whole blood donors

Authors

  • A. Mireille Baart,

    Corresponding author
    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
    • Address reprint requests to: A. Mireille Baart, Sanquin Blood Supply, PO Box 1013, 6501 BA Nijmegen, The Netherlands; e-mail: m.baart@sanquin.nl.

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  • Femke Atsma,

    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
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  • Ellen N. McSweeney,

    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
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  • Karel G.M. Moons,

    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
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  • Yvonne Vergouwe,

    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
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  • Wim L.A.M. de Kort

    1. Department of Donor Studies, Sanquin Research, Nijmegen, the Netherlands
    2. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands
    3. Irish Blood Transfusion Service, Dublin, Ireland
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Abstract

Background

Recently, sex-specific prediction models for low hemoglobin (Hb) deferral have been developed in Dutch whole blood donors. In the present study, we validated and updated the models in a cohort of Irish whole blood donors.

Study Design and Methods

Prospectively collected data from 45,031 Irish whole blood donors were used. Hb cutoff levels for donation were approximately 0.35 mmol/L lower in Ireland than the Dutch cutoff levels (8.07 mmol/L vs. 8.40 mmol/L in men; 7.45 mmol/L vs. 7.80 mmol/L in women). The predictive performance of the models was assessed with calibration plots, calibration-in-the-large, and the concordance (c)-statistic. The models were updated by revising the strength of the individual predictors in the models.

Results

A total of 613 men (2.4%) and 1624 women (8.4%) were deferred from donation because of a low Hb level. Validation demonstrated underestimation of predicted risks and lower c-statistics for men and women compared to the Dutch cohort. The strength of most predictive factors, particularly previous Hb level, was lower in Irish donors. The updated models showed a c-statistic of 0.83 (95% confidence interval [CI], 0.81-0.84) for men and 0.76 (95% CI, 0.74-0.77) for women.

Conclusion

The performance of Dutch prediction models for Hb deferral was limited when validated in Irish whole blood donors. Updating the models resulted in different predictor effects. This improved mainly the model calibration; the improvement in discrimination was small.

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