The minimum number of cord blood units needed for Koreans is 51,000

Authors

  • Jong Hyun Yoon,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Sohee Oh,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Sue Shin,

    Corresponding author
    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
    • Address reprint requests to: Sue Shin, MD, Department of Laboratory Medicine, Seoul National University Boramae Hospital, 39 Boramaegil, Dongjak-gu, Seoul 156-707, Korea; e-mail: jeannie@snu.ac.kr.

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  • Jeong Soo Park,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Eun Youn Roh,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Eun Young Song,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Myoung Hee Park,

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • Kyou Sup Han

    1. Department of Laboratory Medicine, Seoul National University College of Medicine, Seoul, Korea
    2. Department of Laboratory Medicine, Biostatistics, Boramae Hospital, Seoul, Korea
    3. Seoul Metropolitan Government Public Cord Blood Bank (Allcord), Seoul, Korea
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  • [Correction made after online publication 13-June-2013: The spelling of author’s name has been corrected from Moung to Myoung.]
  • This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A062260).

Abstract

Background

The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity.

Study Design and Methods

We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allogeneic hematopoietic stem cell transplantation. Two-digit HLA specificities were determined using intermediate DNA typing. From 17,508 stored Korean CBUs, 1460 haplotypes with a frequency greater than 0.001% were used for reconstitution of the HLA. A total of 1002 transplanted patients' HLA was used for matching probability calculation.

Results

The best probability for 6/6 matching is 47% in 500,000 hypothetical size. Ninety-five percent probability is achieved with 51,000 CBUs in 5/6, and 2150 in 4/6 matching condition. Because 4/6 matched CB is rarely selected in the Korean situation, 51,000 units is the lowest limit of CBUs required and the number will be adjusted depending on the cell number required for patients and the resolution of HLA typing.

Conclusion

Approximately 51,000 units could provide the minimum requirement for hematopoietic transplantation in Korea.

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