[Correction made after online publication 13-June-2013: The spelling of author’s name has been corrected from Moung to Myoung.]
TRANSPLANTATION AND CELLULAR ENGINEERING
The minimum number of cord blood units needed for Koreans is 51,000
Article first published online: 13 JUN 2013
© 2013 American Association of Blood Banks
Volume 54, Issue 3, pages 504–508, March 2014
How to Cite
Yoon, J. H., Oh, S., Shin, S., Park, J. S., Roh, E. Y., Song, E. Y., Park, M. H. and Han, K. S. (2014), The minimum number of cord blood units needed for Koreans is 51,000. Transfusion, 54: 504–508. doi: 10.1111/trf.12284
This study was supported by a grant of the Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea (A062260).
- Issue published online: 11 MAR 2014
- Article first published online: 13 JUN 2013
- Manuscript Accepted: 23 APR 2013
- Manuscript Revised: 18 APR 2013
- Manuscript Received: 19 FEB 2013
- Korea Healthcare Technology R&D Project, Ministry of Health and Welfare, Republic of Korea. Grant Number: A062260
The inventory size for cord blood (CB) depends on the ethnic diversity of human leukocyte antigen (HLA) and the size estimation is important for public health in each ethnicity.
Study Design and Methods
We estimate the CB inventory size in Koreans with stored CB units (CBUs) and patients who underwent allogeneic hematopoietic stem cell transplantation. Two-digit HLA specificities were determined using intermediate DNA typing. From 17,508 stored Korean CBUs, 1460 haplotypes with a frequency greater than 0.001% were used for reconstitution of the HLA. A total of 1002 transplanted patients' HLA was used for matching probability calculation.
The best probability for 6/6 matching is 47% in 500,000 hypothetical size. Ninety-five percent probability is achieved with 51,000 CBUs in 5/6, and 2150 in 4/6 matching condition. Because 4/6 matched CB is rarely selected in the Korean situation, 51,000 units is the lowest limit of CBUs required and the number will be adjusted depending on the cell number required for patients and the resolution of HLA typing.
Approximately 51,000 units could provide the minimum requirement for hematopoietic transplantation in Korea.