REDS-III is supported by NHLBI contracts NHLBI HHSN2682011-00001I, -00002I, -00003I, -00004I, -00005I, -00006I, -00007I, -00008I, and -00009I.
ADVERSE IMPACT OF DONATION
The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): a research program striving to improve blood donor and transfusion recipient outcomes
Article first published online: 4 NOV 2013
© 2013 American Association of Blood Banks
Special Issue: Donating Blood: Who? Why? What of It?
Volume 54, Issue 3pt2, pages 942–955, March 2014
How to Cite
Kleinman, S., Busch, M. P., Murphy, E. L., Shan, H., Ness, P., Glynn, S. A. and The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III) (2014), The National Heart, Lung, and Blood Institute Recipient Epidemiology and Donor Evaluation Study (REDS-III): a research program striving to improve blood donor and transfusion recipient outcomes. Transfusion, 54: 942–955. doi: 10.1111/trf.12468
- Issue published online: 11 MAR 2014
- Article first published online: 4 NOV 2013
- Manuscript Revised: 11 SEP 2013
- Manuscript Accepted: 11 SEP 2013
- Manuscript Received: 25 JUL 2013
- NHLBI. Grant Numbers: HHSN2682011-00001I, HHSN2682011-00002I, HHSN2682011-00003I, HHSN2682011-00004I, HHSN2682011-00005I, HHSN2682011-00006I, HHSN2682011-00007I, HHSN2682011-00008I, HHSN2682011-00009I
The Recipient Epidemiology and Donor Evaluation Study-III (REDS-III) is a 7-year multicenter transfusion safety research initiative launched in 2011 by the National Heart, Lung, and Blood Institute.
Study Design and Methods
The domestic component involves four blood centers, 12 hospitals, a data coordinating center, and a central laboratory. The international component consists of distinct programs in Brazil, China, and South Africa, which involve US and in-country investigators.
REDS-III is using two major methods to address key research priorities in blood banking and transfusion medicine. First, there will be numerous analyses of large “core” databases; the international programs have each constructed a donor and donation database while the domestic program has established a detailed research database that links data from blood donors and their donations, the components made from these donations, and data extracts from the electronic medical records of the recipients of these components. Second, there are more than 25 focused research protocols involving transfusion recipients, blood donors, or both that either are in progress or are scheduled to begin within the next 3 years. Areas of study include transfusion epidemiology and blood utilization, transfusion outcomes, noninfectious transfusion risks, human immunodeficiency virus–related safety issues (particularly in the international programs), emerging infectious agents, blood component quality, donor health and safety, and other donor issues.
It is intended that REDS-III serve as an impetus for more widespread recipient and linked donor–recipient research in the United States as well as to help assure a safe and available blood supply in the United States and in international locations.