These authors contributed equally.
Severe pertussis and hyperleukocytosis: is it time to change for exchange?
Article first published online: 16 DEC 2013
© 2013 AABB
Volume 54, Issue 6, pages 1630–1633, June 2014
How to Cite
Kuperman, A., Hoffmann, Y., Glikman, D., Dabbah, H. and Zonis, Z. (2014), Severe pertussis and hyperleukocytosis: is it time to change for exchange?. Transfusion, 54: 1630–1633. doi: 10.1111/trf.12519
- Issue published online: 9 JUN 2014
- Article first published online: 16 DEC 2013
- Manuscript Accepted: 17 OCT 2013
- Manuscript Revised: 15 OCT 2013
- Manuscript Received: 24 JUL 2013
Pertussis is an important cause of infant death worldwide and continues to be a public health concern even in countries with high vaccination coverage. Severe (critical) pertussis with hyperleukocytosis is a severe form of the disease with up to 80% mortality rate. Attempts have been reported to reduce the white blood cell burden by exchange transfusion (ET) with conflicting conclusions.
We report a case of critical pertussis in a neonate who was treated with ET, in view of a comprehensive literature review.
The patient was discharged without any sequelae.
ET should be considered in all infants suffering from critical pertussis and hyperleukocytosis, even in secondary care community hospitals.