These authors equally contributed to this paper.
Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy
Article first published online: 24 MAR 2014
© 2014 AABB
Volume 54, Issue 9, pages 2175–2181, September 2014
How to Cite
Yeoh, T. Y., Scavonetto, F., Weingarten, T. N., Karnes, R. J., van Buskirk, C. M., Hanson, A. C., Schroeder, D. R. and Sprung, J. (2014), Perioperative allogeneic nonleukoreduced blood transfusion and prostate cancer outcomes after radical prostatectomy. Transfusion, 54: 2175–2181. doi: 10.1111/trf.12595
The Research Electronic Data Capture (REDCap) system is supported by Center for Translational Science Activities (Grant UL1 TR000135). This research was carried out with departmental Small Grant. The funders played no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript.
- Issue published online: 11 SEP 2014
- Article first published online: 24 MAR 2014
- Manuscript Revised: 30 DEC 2013
- Manuscript Accepted: 30 DEC 2013
- Manuscript Received: 4 OCT 2013
- Center for Translational Science Activities. Grant Number: UL1 TR000135
Allogeneic blood transfusion induces immunosuppression, and concern has been raised that it may increase propensity for cancer recurrence; however, these effects have not been confirmed. We examined the association of perioperative transfusion of allogeneic blood long-term oncologic outcomes in patients with prostate cancer who underwent prostatectomy.
Study Design and Methods
We reviewed medical records of patients who underwent radical prostatectomy between 1991 and 2005 and received allogeneic nonleukoreduced blood. Each transfused patient was matched to two controls who did not receive blood: matching included age, surgical year, prostate-specific antigen level, pathologic tumor stages, pathologic Gleason scores, and anesthetic type. Primary outcome was systemic tumor progression, with secondary outcomes of prostate cancer death and all-cause mortality. Stratified proportional hazards regression analysis was used to assess differences in outcomes between the transfused and nontransfused group.
A total of 379 prostatectomy patients who were transfused and 758 nontransfused controls were followed for 9.4 and 10.2 years (median), respectively. In a multivariable analysis that took into account the matched study design and adjusted for positive surgical margins and adjuvant therapies, the use of allogeneic blood was not associated with systemic tumor progression (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.39-1.99; p = 0.76), prostate cancer–specific death (HR, 1.69; 95% CI, 0.44 to 6.48; p = 0.44), or all-cause death (HR, 1.20; 95% CI, 0.87 to 1.67; p = 0.27).
When adjusted for clinicopathologic and procedural variables transfusion of allogeneic blood was not associated with systemic tumor progression and survival outcomes.