Funding support for students (CA, JYSC) was provided through an undergraduate summer research award of the National Science and Engineering Research Council (Canada) and The Ottawa Hospital Foundation. DSA receives salary support from a New Investigator Award from Canadian Institutes of Health Research. DSA and JT are supported in part by the Department of Medicine, University of Ottawa.
Impact of ethnicity on human umbilical cord blood banking: a systematic review
Article first published online: 4 APR 2014
© 2014 AABB
Volume 54, Issue 8, pages 2122–2127, August 2014
How to Cite
Akyurekli, C., Chan, J. Y.S., Elmoazzen, H., Tay, J. and Allan, D. S. (2014), Impact of ethnicity on human umbilical cord blood banking: a systematic review. Transfusion, 54: 2122–2127. doi: 10.1111/trf.12630
- Issue published online: 15 AUG 2014
- Article first published online: 4 APR 2014
- Manuscript Accepted: 13 JAN 2014
- Manuscript Revised: 9 JAN 2014
- Manuscript Received: 22 NOV 2013
- National Science and Engineering Research Council (Canada)
- The Ottawa Hospital Foundation
- Canadian Institutes of Health Research
- Department of Medicine, University of Ottawa
How ethnicity impacts characteristics of umbilical cord blood collected by cord blood banks remains unclear.
Study Design and Methods
After a systematic search, we identified 11 studies for analysis that reported on various variables of collected cord blood units.
Non-Caucasian ethnicity of the cord blood donor was associated with a higher risk of failing to meet banking criteria, lower cord blood volume, reduced total nucleated cell count, fewer CD34+ cells, and reduced colony-forming units.
Non-Caucasian ethnicity is associated with reductions in hematopoietic measures of collected cord blood units. Public banking efforts will have to balance issues related to building ethnic diversity within the bank and maintaining the characteristics of banked units that remain desirable by transplant centers.