Fig. S1. Breakdown of daily cost ($US 2011/2012) of inpatient medications and investigations from 162 patients (without SAE or major bleed) from two UK TOPPS trial centers.

Table S1. Unit costs used to value resource use data in the TOPPS Trial

Table S2. Summary of data for 8 patients who suffered a SAE and for whom detailed inpatient resource use were available

Table S3. Baseline characteristics and primary outcome by trial arm and treatment sub-group

Table S4. Resource use per patient by trial arm for each subgroup

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